SERPINF1 and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SERPINF1	MYOC
Gene Name		serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	myocilin, trabecular meshwork inducible glucocorticoid response
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Melanosome Axon Hillock Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Kidney Development Multicellular Organismal Development Aging Short-term Memory Cell Proliferation Response To Acidic PH Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Endopeptidase Activity Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Ovulation Cycle Response To Arsenic-containing Substance Negative Regulation Of Inflammatory Response Positive Regulation Of Neurogenesis Retina Development In Camera-type Eye Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Cobalt Ion Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Negative Regulation Of Neuron Death	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Drugs
Diseases
GWAS		Calcium levels ( 20705733)
Protein-Protein Interactions		7 interactors: CSNK2A1 EPM2AIP1 LRP6 MLH1 MYOC NEDD4L PNPLA2	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		5176	4653
HPRD ID		01408	03387
Ensembl ID		ENSG00000132386	ENSG00000034971
Uniprot IDs		P36955	Q99972
PDB IDs		1IMV
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Depolarization Wnt Signaling Pathway Regulation Of Cell Junction Assembly Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Skeletal Muscle Hypertrophy Meiotic Metaphase I Plate Congression ERBB2-ERBB3 Signaling Pathway Meiotic Spindle Midzone Assembly Regulation Of Metabolic Process External Genitalia Morphogenesis Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Negative Regulation Of Mitotic Recombination Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure ERBB2 Signaling Pathway Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Positive Regulation Of Caveolin-mediated Endocytosis Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Regulation Of Ion Homeostasis Cell Development Positive Regulation Of Metabolic Process Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Axis Elongation Involved In Somitogenesis Neural Crest Formation Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Glial Cell Differentiation Positive Regulation Of Glycogen (starch) Synthase Activity Mammary Placode Formation Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Acylglycerol Acyl-chain Remodeling Pericardium Morphogenesis Forebrain Radial Glial Cell Differentiation Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Non-canonical Wnt Signaling Pathway Via JNK Cascade Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Bone Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Wnt Signaling Pathway Involved In Somitogenesis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Sodium Ion Transmembrane Transport	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		cel coexpressions colocalization cyst cysts die exhaustively glycoproteins lac lipase lysozyme m1 mapping mining muc6 mucin mucinous multilectin nano nonglycoproteins nonmucinous novoseek ontology periostin pigment proteomic pyruvate quantitation ywhae	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		cel coexpressions colocalization cyst cysts die exhaustively glycoproteins lac lipase lysozyme m1 mapping mining muc6 mucin mucinous multilectin nano nonglycoproteins nonmucinous novoseek ontology periostin pigment proteomic pyruvate quantitation ywhae	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?