SERPINF1 and IMPACT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SERPINF1	IMPACT
Description		serpin family F member 1	impact RWD domain protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Axon Extracellular Matrix Melanosome Neuronal Cell Body Axon Hillock Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Actin Binding Protein Binding Ribosome Binding Protein Sequestering Activity
	Biological Process	Kidney Development Short-term Memory Response To Acidic PH Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Ovulation Cycle Response To Arsenic-containing Substance Positive Regulation Of Neurogenesis Retina Development In Camera-type Eye Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Cobalt Ion Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Response To Peptide	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Regulation Of Translational Initiation Nervous System Development Cell Differentiation Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Positive Regulation Of Neuron Differentiation GCN2-mediated Signaling Neuron Projection Extension Regulation Of Cytoplasmic Translational Initiation In Response To Stress
Pathways			Response of EIF2AK4 (GCN2) to amino acid deficiency
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) Calcium levels ( 20705733)
Interacting Genes		11 interacting genes: CSNK2A1 EPM2AIP1 IMPACT KDR LRP6 MLH1 MYOC NEDD4L PNPLA2 PTPN11 SGTB	5 interacting genes: MAP3K1 PSMB1 SERPINF1 SMURF1 UBC
Entrez ID		5176	55364
HPRD ID		01408	13739
Ensembl ID		ENSG00000132386	ENSG00000154059
Uniprot IDs		A0A140VKF3 P36955	Q9P2X3
PDB IDs		1IMV
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Membrane Depolarization Wnt Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of DNA Recombination Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Biological Quality Positive Regulation Of Catabolic Process Hsp90 Protein Binding Coreceptor Activity Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Cellular Developmental Process Regulation Of Mitochondrial Depolarization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Focal Adhesion Assembly Frizzled Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Skeletal Muscle Hypertrophy Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Triglyceride Metabolic Process Regulation Of Cytoplasmic Translational Initiation In Response To Stress Receptor Tyrosine Kinase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Focal Adhesion Assembly Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Cell-substrate Junction Organization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma ERBB Signaling Pathway Neutral Lipid Metabolic Process Acylglycerol Metabolic Process Intestinal Epithelial Cell Migration TRC Complex Positive Regulation Of Macroautophagy Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Cellular Response To Hydrogen Sulfide Cell Differentiation Male Meiosis Chromosome Segregation MutLalpha Complex Cerebellar Cortex Formation	Modification-dependent Protein Catabolic Process Engulfment Of Target By Autophagosome Proteolysis Involved In Protein Catabolic Process
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