SERPINF1 and NEDD4L

Number of citations of the paper that reports this interaction (PMID 19953087)
25

Data Source:
BioGRID (enzymatic study)

		SERPINF1	NEDD4L
Gene Name		serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Melanosome Axon Hillock Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Ubiquitin-protein Transferase Activity Protein Binding Potassium Channel Regulator Activity Ligase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Ion Channel Binding
	Biological Process	Kidney Development Multicellular Organismal Development Aging Short-term Memory Cell Proliferation Response To Acidic PH Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Endopeptidase Activity Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Ovulation Cycle Response To Arsenic-containing Substance Negative Regulation Of Inflammatory Response Positive Regulation Of Neurogenesis Retina Development In Camera-type Eye Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Cobalt Ion Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Negative Regulation Of Neuron Death	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Depolarization Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Monoubiquitination Sodium Ion Transport Cellular Sodium Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Excretion Response To Salt Stress Response To Metal Ion Gene Expression Positive Regulation Of Sodium Ion Transport Viral Process Protein Ubiquitination Viral Life Cycle Water Homeostasis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Transmembrane Transport Regulation Of Membrane Repolarization Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Positive Regulation Of Cation Channel Activity Positive Regulation Of Caveolin-mediated Endocytosis
Pathways			Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV Life Cycle Budding and maturation of HIV virion Ion channel transport Generic Transcription Pathway Stimuli-sensing channels Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Late Phase of HIV Life Cycle Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Calcium levels ( 20705733)	Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Response to amphetamines ( 22952603)
Protein-Protein Interactions		7 interactors: CSNK2A1 EPM2AIP1 LRP6 MLH1 MYOC NEDD4L PNPLA2	126 interactors: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT3 APEX2 ARHGDIA AURKC BBX BMPR1A BRAF C7orf50 CACNB1 CAMK1D CDC34 CDK3 CDK5 CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 GORAB H1F0 HAX1 HGS IFRD2 IKBKB KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP2 MAP3K2 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 PBX1 PRKX PRR16 PRRG1 PSMD4 RANBP10 RASL10B RASL11B RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SMAD2 SMAD3 SMAD7 SNCA SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TMEM55A TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2N VDAC2 WIBG WNK1 WNK4 YWHAG YWHAZ YY1 ZADH2 ZAK ZC3HAV1L ZDHHC3
Entrez ID		5176	23327
HPRD ID		01408	05903
Ensembl ID		ENSG00000132386	ENSG00000049759
Uniprot IDs		P36955	B7Z2P9 B7Z6K0 F5H602 Q96PU5
PDB IDs		1IMV	2LAJ 2LB2 2LTY 2NSQ 2ONI 3JVZ 3JW0
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Depolarization Wnt Signaling Pathway Regulation Of Cell Junction Assembly Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Skeletal Muscle Hypertrophy Meiotic Metaphase I Plate Congression ERBB2-ERBB3 Signaling Pathway Meiotic Spindle Midzone Assembly Regulation Of Metabolic Process External Genitalia Morphogenesis Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Negative Regulation Of Mitotic Recombination Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure ERBB2 Signaling Pathway Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Positive Regulation Of Caveolin-mediated Endocytosis Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Regulation Of Ion Homeostasis Cell Development Positive Regulation Of Metabolic Process Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Axis Elongation Involved In Somitogenesis Neural Crest Formation Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Glial Cell Differentiation Positive Regulation Of Glycogen (starch) Synthase Activity Mammary Placode Formation Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Acylglycerol Acyl-chain Remodeling Pericardium Morphogenesis Forebrain Radial Glial Cell Differentiation Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Non-canonical Wnt Signaling Pathway Via JNK Cascade Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Bone Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Wnt Signaling Pathway Involved In Somitogenesis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Sodium Ion Transmembrane Transport	Cellular Protein Modification Process Protein Phosphorylation Intracellular Signal Transduction Response To Stimulus Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Protein Polyubiquitination Response To Organic Substance Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Response To Growth Factor Cellular Response To Organic Substance Protein K48-linked Ubiquitination Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Phosphorylation Protein Autophosphorylation Phosphate-containing Compound Metabolic Process Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Transport Cellular Response To Growth Factor Stimulus Cellular Metabolic Process Immune System Process Protein Ubiquitination Regulation Of Cellular Process Positive Regulation Of Protein Ubiquitination Cell Death Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Death Regulation Of Cellular Component Movement
Tagcloud ?		cel coexpressions colocalization cyst cysts die exhaustively glycoproteins lac lipase lysozyme m1 mapping mining muc6 mucin mucinous multilectin nano nonglycoproteins nonmucinous novoseek ontology periostin pigment proteomic pyruvate quantitation ywhae	2cl antihypertensive cotransporter defective demonstrating emerging enac exchanger highlight hypertension interactor interesting liddle ligase makes na ncc nephron nhe3 nkcc2 originally progress salt sensitive thiazide transporters ubiquitin ubiquitylates
Tagcloud (Difference) ?		cel coexpressions colocalization cyst cysts die exhaustively glycoproteins lac lipase lysozyme m1 mapping mining muc6 mucin mucinous multilectin nano nonglycoproteins nonmucinous novoseek ontology periostin pigment proteomic pyruvate quantitation ywhae	2cl antihypertensive cotransporter defective demonstrating emerging enac exchanger highlight hypertension interactor interesting liddle ligase makes na ncc nephron nhe3 nkcc2 originally progress salt sensitive thiazide transporters ubiquitin ubiquitylates
Tagcloud (Intersection) ?