SERPINF1 and PNPLA2

Number of citations of the paper that reports this interaction (PMID 17032652)
55

Data Source:
BioGRID (pull down, pull down)

		SERPINF1	PNPLA2
Gene Name		serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	patatin-like phospholipase domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Melanosome Axon Hillock Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Lipid Particle Cytosol Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Triglyceride Lipase Activity
	Biological Process	Kidney Development Multicellular Organismal Development Aging Short-term Memory Cell Proliferation Response To Acidic PH Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Endopeptidase Activity Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Ovulation Cycle Response To Arsenic-containing Substance Negative Regulation Of Inflammatory Response Positive Regulation Of Neurogenesis Retina Development In Camera-type Eye Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Cobalt Ion Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Negative Regulation Of Neuron Death	Phospholipid Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Particle Organization Acylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways			Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS		Calcium levels ( 20705733)
Protein-Protein Interactions		7 interactors: CSNK2A1 EPM2AIP1 LRP6 MLH1 MYOC NEDD4L PNPLA2	10 interactors: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		5176	57104
HPRD ID		01408	11443
Ensembl ID		ENSG00000132386	ENSG00000177666
Uniprot IDs		P36955	Q96AD5
PDB IDs		1IMV
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Depolarization Wnt Signaling Pathway Regulation Of Cell Junction Assembly Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Skeletal Muscle Hypertrophy Meiotic Metaphase I Plate Congression ERBB2-ERBB3 Signaling Pathway Meiotic Spindle Midzone Assembly Regulation Of Metabolic Process External Genitalia Morphogenesis Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Negative Regulation Of Mitotic Recombination Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure ERBB2 Signaling Pathway Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Positive Regulation Of Caveolin-mediated Endocytosis Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Regulation Of Ion Homeostasis Cell Development Positive Regulation Of Metabolic Process Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Axis Elongation Involved In Somitogenesis Neural Crest Formation Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Glial Cell Differentiation Positive Regulation Of Glycogen (starch) Synthase Activity Mammary Placode Formation Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Acylglycerol Acyl-chain Remodeling Pericardium Morphogenesis Forebrain Radial Glial Cell Differentiation Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Non-canonical Wnt Signaling Pathway Via JNK Cascade Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Bone Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Wnt Signaling Pathway Involved In Somitogenesis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Sodium Ion Transmembrane Transport	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Post-Golgi Vesicle-mediated Transport Cellular Response To Cobalt Ion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Catalytic Activity Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Triglyceride Catabolic Process Regulation Of GTPase Activity Mullerian Duct Regression Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Receptor Recycling Response To Cobalt Ion Golgi Vesicle Transport Short-term Memory COPI-coated Vesicle Budding Positive Regulation Of Lipoprotein Lipase Activity COPI Coating Of Golgi Vesicle Positive Regulation Of Metabolic Process
Tagcloud ?		cel coexpressions colocalization cyst cysts die exhaustively glycoproteins lac lipase lysozyme m1 mapping mining muc6 mucin mucinous multilectin nano nonglycoproteins nonmucinous novoseek ontology periostin pigment proteomic pyruvate quantitation ywhae	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Difference) ?		cel coexpressions colocalization cyst cysts die exhaustively glycoproteins lac lipase lysozyme m1 mapping mining muc6 mucin mucinous multilectin nano nonglycoproteins nonmucinous novoseek ontology periostin pigment proteomic pyruvate quantitation ywhae	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Intersection) ?