NLK and HIPK2

Number of citations of the paper that reports this interaction (PMID 15082531)
49

Data Source:
HPRD (in vitro, two hybrid)

		NLK	HIPK2
Gene Name		nemo-like kinase	homeodomain interacting protein kinase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm Nuclear Body PML Body RNA Polymerase II Transcription Factor Complex
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding SH2 Domain Binding	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SMAD Binding Virion Binding
	Biological Process	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Serine Phosphorylation Of STAT3 Protein Intracellular Signal Transduction Protein Autophosphorylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Eye Development Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Neuron Differentiation Erythrocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Positive Regulation Of Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway
Pathways		Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling	Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ASGR1 ATXN1 CHD7 CREBBP CUL1 FBXW5 FOXO4 GRN HIPK2 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 PPARG QRICH1 RCHY1 SDR16C5 SKP2 STAT3 STAT5A USP4 ZHX3	48 interactors: AATF BTRC CHMP4B CREBBP CUL1 CXCL1 DAXX DDX39A DDX39B EP300 FBXW7 HIST2H2BE HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK PAX6 PML PTCH1 RANBP9 RUNX1 SENP1 SIAH1 SIAH2 SKI SMAD1 SMAD2 SMAD3 SP100 SUMO1 SUMO2 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4
Entrez ID		51701	28996
HPRD ID		17637	06039
Ensembl ID		ENSG00000087095	ENSG00000064393
Uniprot IDs		Q9UBE8	Q9H2X6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Leukocyte Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Hemopoiesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Immune System Development Radial Glial Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Developmental Process Lymphocyte Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Anatomical Structure Development Modification-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Multicellular Organism Growth Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Catabolic Process Cellular Response To Oxygen Levels Organ Development Regulation Of Cell Cycle Cellular Response To Hormone Stimulus	Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Response To Organic Substance Apoptotic Process Transcription, DNA-templated Cellular Response To Organic Substance Tube Development Regulation Of Signaling Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Response To Stimulus Cell Death Death Regulation Of Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Cell Proliferation Cell Cycle RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Cell Cycle Process Regulation Of Cell Cycle Cell Communication Gene Expression Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway
Tagcloud ?		adenomatosis apr asymmetric asymmetry caenorhabditis divisions evolutionarily fates heterochronic illuminate lin lineages lit opposing pharynx polarity polarizing polyposis pop postembryonic proceeds renewing robustly seam symmetric tcf timing transitions wingless	adding complexity decisions determines e3 fail fate favoring feedback finger homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313
Tagcloud (Difference) ?		adenomatosis apr asymmetric asymmetry caenorhabditis divisions evolutionarily fates heterochronic illuminate lin lineages lit opposing pharynx polarity polarizing polyposis pop postembryonic proceeds renewing robustly seam symmetric tcf timing transitions wingless	adding complexity decisions determines e3 fail fate favoring feedback finger homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313
Tagcloud (Intersection) ?