NLK and MYB

Number of citations of the paper that reports this interaction (PMID 15082531)
49

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		NLK	MYB
Gene Name		nemo-like kinase	v-myb avian myeloblastosis viral oncogene homolog
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytosol Nuclear Matrix
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding SH2 Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding WD40-repeat Domain Binding
	Biological Process	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Serine Phosphorylation Of STAT3 Protein Intracellular Signal Transduction Protein Autophosphorylation	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Calcium Ion Transport Blood Coagulation B Cell Differentiation Positive Regulation Of T-helper Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Embryonic Digestive Tract Development Homeostasis Of Number Of Cells Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K9 Methylation Cellular Response To Interleukin-6
Pathways		Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Beta thalassemia/hemoglobin E disease ( 20183929) HbA2 levels ( 23043469) Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular hemoglobin concentration ( 23263863 20139978) Mean corpuscular volume ( 23263863 20139978 19862010) Mean platelet volume ( 22423221) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet counts ( 22139419 20139978) Red blood cell count ( 20139978) Red blood cell traits ( 20927387) White blood cell count ( 20139978) White blood cell types ( 21738478)
Protein-Protein Interactions		25 interactors: ASGR1 ATXN1 CHD7 CREBBP CUL1 FBXW5 FOXO4 GRN HIPK2 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 PPARG QRICH1 RCHY1 SDR16C5 SKP2 STAT3 STAT5A USP4 ZHX3	43 interactors: BTRC CCND3 CEBPB CEBPE CHD3 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAX5 PIAS1 PML PPM1K RBX1 RPL4 RQCD1 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11
Entrez ID		51701	4602
HPRD ID		17637	01810
Ensembl ID		ENSG00000087095	ENSG00000118513
Uniprot IDs		Q9UBE8	P10242 Q14025 Q708E1 Q708E9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Leukocyte Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Hemopoiesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Immune System Development Radial Glial Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Developmental Process Lymphocyte Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Anatomical Structure Development Modification-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Multicellular Organism Growth Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Catabolic Process Cellular Response To Oxygen Levels Organ Development Regulation Of Cell Cycle Cellular Response To Hormone Stimulus	RNA Biosynthetic Process Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Protein Sumoylation Cellular Protein Modification Process Rhythmic Process Protein Modification By Small Protein Conjugation Developmental Process Peptidyl-lysine Modification PML Body Organization Cell Cycle Regulation Of Signal Transduction Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process
Tagcloud ?		adenomatosis apr asymmetric asymmetry caenorhabditis divisions evolutionarily fates heterochronic illuminate lin lineages lit opposing pharynx polarity polarizing polyposis pop postembryonic proceeds renewing robustly seam symmetric tcf timing transitions wingless	amphibian amphibians assume definitive deoxynucleotidyl ectotherms elasmobranchs elegant extraembryonic gata gnathostomes grafting hematopoiesis icm ikaros intraembryonic lck leydig lymphopoiesis mesoderm myeloblastosis oellacher primitive rag spiral tdt teleosts thymopoietic undeniably vertebrates
Tagcloud (Difference) ?		adenomatosis apr asymmetric asymmetry caenorhabditis divisions evolutionarily fates heterochronic illuminate lin lineages lit opposing pharynx polarity polarizing polyposis pop postembryonic proceeds renewing robustly seam symmetric tcf timing transitions wingless	amphibian amphibians assume definitive deoxynucleotidyl ectotherms elasmobranchs elegant extraembryonic gata gnathostomes grafting hematopoiesis icm ikaros intraembryonic lck leydig lymphopoiesis mesoderm myeloblastosis oellacher primitive rag spiral tdt teleosts thymopoietic undeniably vertebrates
Tagcloud (Intersection) ?