NLK and FOXO4

Number of citations of the paper that reports this interaction (PMID 20874444)
1

Data Source:
BioGRID (enzymatic study)

		NLK	FOXO4
Gene Name		nemo-like kinase	forkhead box O4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding SH2 Domain Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enzyme Binding Sequence-specific DNA Binding
	Biological Process	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Serine Phosphorylation Of STAT3 Protein Intracellular Signal Transduction Protein Autophosphorylation	Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Mitotic G2 DNA Damage Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Angiogenesis Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Stem Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of G0 To G1 Transition
Pathways		Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ASGR1 ATXN1 CHD7 CREBBP CUL1 FBXW5 FOXO4 GRN HIPK2 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 PPARG QRICH1 RCHY1 SDR16C5 SKP2 STAT3 STAT5A USP4 ZHX3	14 interactors: AKT1 AKT2 CREBBP CTNNB1 ESR1 FOXG1 NLK PIN1 REL SFN SMAD3 SMAD4 XPO1 YWHAZ
Entrez ID		51701	4303
HPRD ID		17637	02070
Ensembl ID		ENSG00000087095	ENSG00000184481
Uniprot IDs		Q9UBE8	P98177
PDB IDs			1E17 3L2C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Leukocyte Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Hemopoiesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Immune System Development Radial Glial Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Developmental Process Lymphocyte Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Anatomical Structure Development Modification-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Multicellular Organism Growth Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Catabolic Process Cellular Response To Oxygen Levels Organ Development Regulation Of Cell Cycle Cellular Response To Hormone Stimulus	Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Regulation Of Protein Localization Epithelial Cell Differentiation Regulation Of Organelle Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Signal Transduction Regulation Of Establishment Of Protein Localization Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Organelle Organization Signaling Cell Communication Response To Organic Substance Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Gene Expression Gland Development Negative Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cytokine Production Regulation Of Cell Cycle Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Cell Death Cellular Response To Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Epithelium Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Signaling Positive Regulation Of Transport
Tagcloud ?		adenomatosis apr asymmetric asymmetry caenorhabditis divisions evolutionarily fates heterochronic illuminate lin lineages lit opposing pharynx polarity polarizing polyposis pop postembryonic proceeds renewing robustly seam symmetric tcf timing transitions wingless	aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo1 foxo3a harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing ubr2 wasting
Tagcloud (Difference) ?		adenomatosis apr asymmetric asymmetry caenorhabditis divisions evolutionarily fates heterochronic illuminate lin lineages lit opposing pharynx polarity polarizing polyposis pop postembryonic proceeds renewing robustly seam symmetric tcf timing transitions wingless	aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo1 foxo3a harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing ubr2 wasting
Tagcloud (Intersection) ?