TRIM38 and EIF1B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TRIM38	EIF1B
Description		tripartite motif containing 38	eukaryotic translation initiation factor 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Eukaryotic 43S Preinitiation Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosomal Small Subunit Binding
	Biological Process	Immune System Process Regulation Of Gene Expression Protein Ubiquitination Protein Sumoylation Regulation Of Interferon-beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Process Negative Regulation Of Defense Response To Virus Protein K48-linked Ubiquitination Regulation Of Viral Life Cycle	Translation Translational Initiation Regulation Of Translational Initiation Regulation Of Gene Expression Regulation Of Primary Metabolic Process
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Fish- and plant-related diet ( 32066663) Height ( 28552196) Iron status biomarkers ( 19084217) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Refractive error ( 32231278)
Interacting Genes		30 interacting genes: ATXN1 BYSL EIF1B GMCL1 GORASP2 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 MTURN PIAS4 PSMA4 RFC5 RIPK1 RNF4 SDCBP STXBP1 TCEA2 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U ZNF764	7 interacting genes: ATXN1 DVL2 DVL3 GRSF1 PEX19 SPG21 TRIM38
Entrez ID		10475	10289
HPRD ID		15555	17032
Ensembl ID		ENSG00000112343	ENSG00000114784
Uniprot IDs		O00635	O60739 Q6FG85
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination ATP Binding Protein Refolding Protein Polyubiquitination ATP-dependent Protein Folding Chaperone Protein K11-linked Ubiquitination Ubiquitin-protein Transferase Activity Nucleotide Binding Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation C3HC4-type RING Finger Domain Binding Protein Folding Chaperone Blood Microparticle ATP-dependent Protein Disaggregase Activity Heat Shock Protein Binding Post-translational Protein Modification Response To Unfolded Protein Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Protein Ubiquitination Unfolded Protein Binding Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification Process Nucleoplasm Regulation Of Inclusion Body Assembly Macromolecule Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Transferase Activity Protein K63-linked Ubiquitination Protein K6-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus ISG15 Transferase Activity Ubiquitin Protein Ligase Binding Cellular Response To Stress Regulation Of Spindle Assembly Catabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Metabolic Process Protein Folding Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Protein Localization To Chromatin ISG15-protein Conjugation Positive Regulation Of Myeloid Cell Differentiation ATP Hydrolysis Activity	Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Non-canonical Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Canonical Wnt Signaling Pathway Positive Regulation Of JNK Cascade Peroxisome Membrane Targeting Sequence Binding Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Mitochondrial RNA Catabolic Process Peroxisome Membrane Biogenesis Regulation Of JNK Cascade POZ Domain Binding Cytoplasm Convergent Extension Involved In Organogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Convergent Extension Involved In Gastrulation Protein Import Into Peroxisome Membrane Locomotory Behavior Mitochondrial RNA Catabolic Process Membrane Biogenesis Positive Regulation Of Macromolecule Metabolic Process G-quadruplex RNA Binding Poly(G) Binding Wnt Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Morphogenesis Regionalization Cytosol Protein Stabilization Protein Targeting To Peroxisome Protein Carrier Chaperone Peroxisome Fission Nuclear Inclusion Body Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway CD4 Receptor Binding Convergent Extension Small GTPase Binding Ribonucleoprotein Granule Positive Regulation Of Viral Entry Into Host Cell Regulation Of Nucleobase-containing Compound Metabolic Process Segment Specification Negative Regulation Of Defense Response To Virus
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