TRIM38 and RIPK1

Number of citations of the paper that reports this interaction (PMID 11854271)
6

Data Source:
HPRD (in vivo, two hybrid)

		TRIM38	RIPK1
Gene Name		tripartite motif containing 38	receptor (TNFRSF)-interacting serine-threonine kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol	Cytoplasm Mitochondrion Cytosol Death-inducing Signaling Complex Receptor Complex Membrane Raft Ripoptosome
	Molecular Function	Signal Transducer Activity Zinc Ion Binding Ligase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Death Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Identical Protein Binding Death Domain Binding
	Biological Process	Cytokine-mediated Signaling Pathway Regulation Of Interferon-beta Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Protein K48-linked Ubiquitination	Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-serine Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Catabolic Process Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Protein Heterooligomerization Positive Regulation Of Necroptotic Process T Cell Apoptotic Process Necroptotic Process Regulation Of ATP:ADP Antiporter Activity Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Ripoptosome Assembly Necroptotic Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Regulation by c-FLIP Caspase-8 activation by cleavage Dimerization of procaspase-8 IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Iron status biomarkers ( 19084217)
Protein-Protein Interactions		21 interactors: ATXN1 EIF1B GMCL1 GORASP2 HSPA1A HSPA2 HSPA8 RFC5 RIPK1 SDCBP STXBP1 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U	45 interactors: BIRC2 BIRC3 CASP8 CCDC50 CDC42BPB CFLAR CRADD EGFR FADD FAS HSP90AA1 IKBKB IKBKG ITCH MAP3K14 MAP3K3 MAP3K8 NFKB1 NUMBL OTUD1 PELI1 PTK2 RIPK3 RNF11 RNF216 SQSTM1 TAX1BP1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRIM38 TRPC4AP UBE2N USP2 XIAP YOD1 ZFAND5
Entrez ID		10475	8737
HPRD ID		15555	04583
Ensembl ID		ENSG00000112343	ENSG00000137275
Uniprot IDs		B2R862 O00635	Q13546
PDB IDs			4ITH 4ITI 4ITJ
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Toll-like Receptor 3 Signaling Pathway Protein Catabolic Process Protein Refolding Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Toll-like Receptor Signaling Pathway Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteolysis Involved In Cellular Protein Catabolic Process Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress ISG15-protein Conjugation Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Innate Immune Response Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Inclusion Body Assembly Response To Stress Regulation Of Innate Immune Response Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transferase Activity Regulation Of Inclusion Body Assembly Cellular Response To Oxygen Levels Cellular Protein Modification Process Response To Unfolded Protein Response To Abiotic Stimulus Regulation Of Cellular Response To Heat Cellular Metabolic Process Mitotic Spindle Assembly Checkpoint Histone Ubiquitination Spindle Assembly Checkpoint	Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Metabolic Process Innate Immune Response Positive Regulation Of Cellular Metabolic Process Signal Transduction Immune Response NIK/NF-kappaB Signaling Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signaling Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Type I Interferon Production Cellular Response To Mechanical Stimulus Cell Communication Defense Response Positive Regulation Of Protein Modification Process
Tagcloud ?			allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin mlkl necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk3 stress stressors switch tnfr1 unresolved
Tagcloud (Difference) ?			allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin mlkl necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk3 stress stressors switch tnfr1 unresolved
Tagcloud (Intersection) ?