TRIM38 and HSPA1L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM38	HSPA1L
Description		tripartite motif containing 38	heat shock protein family A (Hsp70) member 1 like
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Zona Pellucida Receptor Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Cell Body Blood Microparticle
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Immune System Process Regulation Of Gene Expression Protein Ubiquitination Protein Sumoylation Regulation Of Interferon-beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Process Negative Regulation Of Defense Response To Virus Protein K48-linked Ubiquitination Regulation Of Viral Life Cycle	Protein Folding Response To Stress Response To Unfolded Protein Binding Of Sperm To Zona Pellucida Protein Refolding Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Interferon gamma signaling	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation PKR-mediated signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Fish- and plant-related diet ( 32066663) Height ( 28552196) Iron status biomarkers ( 19084217) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908)
Interacting Genes		30 interacting genes: ATXN1 BYSL EIF1B GMCL1 GORASP2 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 MTURN PIAS4 PSMA4 RFC5 RIPK1 RNF4 SDCBP STXBP1 TCEA2 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U ZNF764	5 interacting genes: BAG4 HRAS LINC01554 PTPRF TRIM38
Entrez ID		10475	3305
HPRD ID		15555	00776
Ensembl ID		ENSG00000112343	ENSG00000204390
Uniprot IDs		O00635	A0A1U9X7W7 P34931
PDB IDs			3GDQ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination ATP Binding Protein Refolding Protein Polyubiquitination ATP-dependent Protein Folding Chaperone Protein K11-linked Ubiquitination Ubiquitin-protein Transferase Activity Nucleotide Binding Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation C3HC4-type RING Finger Domain Binding Protein Folding Chaperone Blood Microparticle ATP-dependent Protein Disaggregase Activity Heat Shock Protein Binding Post-translational Protein Modification Response To Unfolded Protein Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Protein Ubiquitination Unfolded Protein Binding Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification Process Nucleoplasm Regulation Of Inclusion Body Assembly Macromolecule Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Transferase Activity Protein K63-linked Ubiquitination Protein K6-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus ISG15 Transferase Activity Ubiquitin Protein Ligase Binding Cellular Response To Stress Regulation Of Spindle Assembly Catabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Metabolic Process Protein Folding Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Protein Localization To Chromatin ISG15-protein Conjugation Positive Regulation Of Myeloid Cell Differentiation ATP Hydrolysis Activity	Chondroitin Sulfate Proteoglycan Binding Negative Regulation Of MRNA Modification GTPase Complex
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