TRIM38

Gene Name		tripartite motif containing 38
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol
	Molecular Function	Signal Transducer Activity Zinc Ion Binding Ligase Activity
	Biological Process	Cytokine-mediated Signaling Pathway Regulation Of Interferon-beta Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Protein K48-linked Ubiquitination
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Iron status biomarkers ( 19084217)
Protein-protein Interactions		21 interactors: ATXN1 EIF1B GMCL1 GORASP2 HSPA1A HSPA2 HSPA8 RFC5 RIPK1 SDCBP STXBP1 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U
Entrez ID		10475
HPRD ID		15555
Ensembl ID		ENSG00000112343
Uniprot IDs		B2R862 O00635
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Toll-like Receptor 3 Signaling Pathway Protein Catabolic Process Protein Refolding Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Toll-like Receptor Signaling Pathway Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteolysis Involved In Cellular Protein Catabolic Process Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress ISG15-protein Conjugation Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Innate Immune Response Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Inclusion Body Assembly Response To Stress Regulation Of Innate Immune Response Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transferase Activity Regulation Of Inclusion Body Assembly Cellular Response To Oxygen Levels Cellular Protein Modification Process Response To Unfolded Protein Response To Abiotic Stimulus Regulation Of Cellular Response To Heat Cellular Metabolic Process Mitotic Spindle Assembly Checkpoint Histone Ubiquitination Spindle Assembly Checkpoint
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