TAP1 and KRTAP4-12

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TAP1	KRTAP4-12
Description		transporter 1, ATP binding cassette subfamily B member	keratin associated protein 4-12
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Phagocytic Vesicle Membrane Organelle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Centriolar Satellite MHC Class I Peptide Loading Complex TAP Complex	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity MHC Class Ib Protein Binding MHC Protein Binding MHC Class I Protein Binding Peptide Antigen Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding TAP1 Binding TAP2 Binding ABC-type Transporter Activity Peptide Transmembrane Transporter Activity	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class I Protein Complex Defense Response Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Transmembrane Transport	Hair Cycle
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type1
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Metabolite levels ( 23823483) Nephropathy ( 21399633)
Interacting Genes		27 interacting genes: AQP6 CHRM3 CREB3 ERGIC3 ERVFRD-1 ESR1 GEMIN4 GPR152 HLA-F HLA-G KRTAP4-12 LCE2C LMNA MDFI MUL1 PDIA3 PSMB5 PSMB8 RNF19B SLC10A1 SLC10A6 SLC35H1 SSMEM1 TAP2 TAPBP TDP2 TMEM14B	160 interacting genes: ADAM12 ADAMTSL4 ALPP AQP1 ATG12 ATN1 AXIN1 BAG4 BAHD1 BEX2 C10orf62 CATSPER1 CBX2 CCDC116 CCDC185 CCNK CDC42EP1 CDX2 CHCHD3 CHIC2 CHRD CLCNKA CLDN2 CNNM3 CNTFR COL8A1 CRCT1 CREB5 CRY1 CYSRT1 DBF4B DLK2 EIF4E2 ELOA2 FAM107A FAM27E3 FAM76B FBXL18 FBXO34 FBXW5 FCHO1 FUCA2 GLRX3 GNE GPATCH2L GPRIN2 GRAP2 HHEX HOXA1 HOXB9 IFI30 IGSF8 ILF3 KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP4-2 KRTAP4-4 KRTAP5-1 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 MAPKBP1 MEOX2 MRPL4 NBPF19 NOTCH2NLA NPDC1 NUDT18 NUFIP2 OTX1 PCSK5 PDGFRB PFKL PHLDA1 PLSCR1 PLSCR4 PNKP POU4F2 PRKAB2 PRKAG1 PRR13 PTPMT1 QPRT R3HDM2 RERE RPS28 SHFL SLC25A10 SLC25A6 SMCP SPATA3 SPG7 SPRY1 SPRY2 TAP1 TBC1D16 TBC1D23 TGM1 THAP10 THAP7 TOP3B TXNDC5 ZBTB16 ZNF165 ZNF20 ZNF250 ZNF408 ZNF414 ZNF415 ZNF417 ZNF426 ZNF439 ZNF440 ZNF497 ZNF581 ZNF638 ZNF655 ZNF696 ZNF764 ZNF837 ZSCAN26
Entrez ID		6890	83755
HPRD ID		01359	13941
Ensembl ID		ENSG00000168394	ENSG00000213416
Uniprot IDs		A0A0S2Z5A6 B7Z7P4 Q03518 X5CKB3	Q9BQ66
PDB IDs		1JJ7 5U1D 8T46 8T4E 8T4F 8T4G 8T4H 8T4I 8T4J
Enriched GO Terms of Interacting Partners?		TAP1 Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen MHC Class I Peptide Loading Complex Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Peptide Antigen Assembly With MHC Class I Protein Complex Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Tapasin-ERp57 Complex Antigen Processing And Presentation Of Peptide Antigen TAP2 Binding Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of T Cell Mediated Cytotoxicity Bile Acid:sodium Symporter Activity Regulation Of T Cell Mediated Cytotoxicity MHC Class I Protein Complex Positive Regulation Of Natural Killer Cell Cytokine Production Threonine-type Endopeptidase Activity Regulation Of Natural Killer Cell Cytokine Production Proteasome Core Complex, Beta-subunit Complex Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of T Cell Mediated Immunity Identical Protein Binding Endoplasmic Reticulum Proteasome Core Complex Regulation Of Leukocyte Mediated Cytotoxicity Negative Regulation Of Innate Immune Response Bile Acid And Bile Salt Transport Recycling Endosome Membrane Regulation Of T Cell Mediated Immunity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Lymphocyte Mediated Immunity Nitrate Transmembrane Transporter Activity Protein Binding Membrane Endoplasmic Reticulum Membrane 14-3-3 Protein Binding Adaptive Immune Response Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Negative Regulation Of Natural Killer Cell Degranulation	Intermediate Filament Keratinization Keratin Filament Epidermis Development Protein Binding Tissue Development Identical Protein Binding
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