TAP1 and TAP2

Number of citations of the paper that reports this interaction (PMID 11381133)
6

Data Source:
HPRD (in vivo, in vitro)

		TAP1	TAP2
Gene Name		transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane TAP Complex	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane TAP Complex
	Molecular Function	Protein Binding ATP Binding Peptide Transporter Activity Peptide-transporting ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity ADP Binding TAP1 Binding TAP2 Binding	Transporter Activity Protein Binding ATP Binding Peptide Transporter Activity Peptide Antigen-transporting ATPase Activity MHC Class Ib Protein Binding TAP1 Binding Tapasin Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Metabolic Process Peptide Transport Intracellular Transport Of Viral Protein In Host Cell Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Transmembrane Transport	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Metabolic Process Intracellular Transport Of Viral Protein In Host Cell Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Peptide Antigen Transport Transmembrane Transport
Pathways		Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS		Nephropathy ( 21399633)	Lymphoma ( 23349640) Nephropathy ( 21399633) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		12 interactors: ESR1 HLA-F HLA-G KRTAP4-12 MDFI MUL1 PDIA3 PSMB5 PSMB8 TAP2 TAPBP TDP2	9 interactors: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP
Entrez ID		6890	6891
HPRD ID		01359	01360
Ensembl ID		ENSG00000168394	ENSG00000204267
Uniprot IDs		F5H648 Q03518	Q03519 Q9UP03
PDB IDs		1JJ7
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Positive Regulation Of Signal Transduction Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Response To Stress Cellular Response To Stress Signal Transduction Negative Regulation Of Signal Transduction Signaling Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transferase Activity Cell Communication Negative Regulation Of Signaling Activation Of JUN Kinase Activity Response To Stimulus Regulation Of Apoptotic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Stimulus Regulation Of Wnt Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Catalytic Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Cell Death Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of JUN Kinase Activity Peptide Antigen Stabilization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Modification Process Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of JUN Kinase Activity	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Viral Process Immune Response Defense Response Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Innate Immune Response Positive Regulation Of Cell Cycle Response To Stress Positive Regulation Of Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of T Cell Mediated Cytotoxicity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Cytokine-mediated Signaling Pathway Positive Regulation Of Ligase Activity Regulation Of T Cell Mediated Cytotoxicity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Peptide Antigen Stabilization Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		activates acts blocks contain crossover crossovers demonstrating dominan ecs element gamma gas hela homodimers ifn isre jak1 jaks janus p48 permits phosphatase shp ss stat1 stat1alpha stat2 transporter tyk	beta2 blocker chains clamp class confocal detectable dissociated drastically electric electrophysiological electrophysiology exceptions heavy ifn mhc microglobulin neurons neurotransmitter partly patch reverted tap1 tetrodotoxin transcribe transcribed transporters upregulate
Tagcloud (Difference) ?		activates acts blocks contain crossover crossovers demonstrating dominan ecs element gamma gas hela homodimers isre jak1 jaks janus p48 permits phosphatase shp ss stat1 stat1alpha stat2 transporter tyk	beta2 blocker chains clamp class confocal detectable dissociated drastically electric electrophysiological electrophysiology exceptions heavy mhc microglobulin neurons neurotransmitter partly patch reverted tetrodotoxin transcribe transcribed transporters upregulate
Tagcloud (Intersection) ?		ifn tap1