TAP1 and CHRM3

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TAP1	CHRM3
Description		transporter 1, ATP binding cassette subfamily B member	cholinergic receptor muscarinic 3
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Phagocytic Vesicle Membrane Organelle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Centriolar Satellite MHC Class I Peptide Loading Complex TAP Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity MHC Class Ib Protein Binding MHC Protein Binding MHC Class I Protein Binding Peptide Antigen Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding TAP1 Binding TAP2 Binding ABC-type Transporter Activity Peptide Transmembrane Transporter Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Signaling Receptor Activity Acetylcholine Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class I Protein Complex Defense Response Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Transmembrane Transport	Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Muscarinic acetylcholine receptors Acetylcholine regulates insulin secretion G alpha (q) signalling events
Drugs			Cevimeline Tramadol Succinylcholine Trospium Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Chlorpromazine Darifenacin Haloperidol Tridihexethyl Anisotropine methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Thiopental Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Dicyclomine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine Arecoline Mepenzolate ALKS 27 Pizotifen Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Diphemanil Aripiprazole lauroxil
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type1
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Metabolite levels ( 23823483) Nephropathy ( 21399633)	Acute respiratory distress syndrome ( 34032881) Chronic obstructive pulmonary disease ( 30804561) Colorectal cancer ( 29228715) Depression in smokers ( 30219690) Electroencephalogram traits ( 25387704) Feeling worry ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) FEV1 ( 30804560) Generalized epilepsy ( 22949513) Gut microbiota beta diversity (weighted UniFrac distance) ( 33208821) Hallucinations in long-term cannabis use ( 31740666) Hypertension ( 17554300) Interleukin-6 (red blood cell fatty acid level interaction) ( 28820441) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) Platelet count ( 21507922) Post bronchodilator FEV1 ( 26634245) Reflection (response to stress) ( 30886212) Sulfasalazine-induced agranulocytosis ( 28762467) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		27 interacting genes: AQP6 CHRM3 CREB3 ERGIC3 ERVFRD-1 ESR1 GEMIN4 GPR152 HLA-F HLA-G KRTAP4-12 LCE2C LMNA MDFI MUL1 PDIA3 PSMB5 PSMB8 RNF19B SLC10A1 SLC10A6 SLC35H1 SSMEM1 TAP2 TAPBP TDP2 TMEM14B	26 interacting genes: ARF1 ARF6 BSG CALM3 CCDC184 CD2BP2 COMMD7 CSNK1A1 GNAQ GNAS GPRASP1 GRK6 GZMB JAKMIP1 MAGED2 POM121C PPP1R9B RAB5IF RGS7 SEPTIN3 SET SGSM3 SNCA TAP1 TPM3 YIPF3
Entrez ID		6890	1131
HPRD ID		01359	00329
Ensembl ID		ENSG00000168394	ENSG00000133019
Uniprot IDs		A0A0S2Z5A6 B7Z7P4 Q03518 X5CKB3	P20309
PDB IDs		1JJ7 5U1D 8T46 8T4E 8T4F 8T4G 8T4H 8T4I 8T4J	2CSA 8E9W 8E9Y 8E9Z 8EA0
Enriched GO Terms of Interacting Partners?		TAP1 Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen MHC Class I Peptide Loading Complex Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Peptide Antigen Assembly With MHC Class I Protein Complex Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Tapasin-ERp57 Complex Antigen Processing And Presentation Of Peptide Antigen TAP2 Binding Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of T Cell Mediated Cytotoxicity Bile Acid:sodium Symporter Activity Regulation Of T Cell Mediated Cytotoxicity MHC Class I Protein Complex Positive Regulation Of Natural Killer Cell Cytokine Production Threonine-type Endopeptidase Activity Regulation Of Natural Killer Cell Cytokine Production Proteasome Core Complex, Beta-subunit Complex Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of T Cell Mediated Immunity Identical Protein Binding Endoplasmic Reticulum Proteasome Core Complex Regulation Of Leukocyte Mediated Cytotoxicity Negative Regulation Of Innate Immune Response Bile Acid And Bile Salt Transport Recycling Endosome Membrane Regulation Of T Cell Mediated Immunity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Lymphocyte Mediated Immunity Nitrate Transmembrane Transporter Activity Protein Binding Membrane Endoplasmic Reticulum Membrane 14-3-3 Protein Binding Adaptive Immune Response Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Negative Regulation Of Natural Killer Cell Degranulation	GTPase Activity Regulation Of Endocytosis Response To Prostaglandin E Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Adenylate Cyclase Activator Activity Presynaptic Endocytosis Cellular Localization Establishment Of Protein Localization Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport G Protein Activity Intracellular Protein Localization GTP Binding Positive Regulation Of Protein Localization To Cell Periphery Guanyl Nucleotide Binding Establishment Of Localization In Cell Vesicle-mediated Transport In Synapse Response To Ketone Cellular Response To Acidic PH Presynapse G-protein Beta/gamma-subunit Complex Binding GTPase Activator Activity Response To Alcohol Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Response To Acidic PH Nucleotide Binding Regulation Of Cell Communication Protein Transport Regulation Of Signaling Mitotic Cleavage Furrow Ingression Membrane Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Response To Growth Factor Erythrocyte Apoptotic Process Growth Cone G Protein-coupled Receptor Signaling Pathway Response To Amphetamine Postsynaptic Cytosol Regulation Of Synaptic Vesicle Recycling Cellular Response To PH Heterotrimeric G-protein Complex Positive Regulation Of Catalytic Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity
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