TAP1

Gene Name		transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
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Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane TAP Complex
	Molecular Function	Protein Binding ATP Binding Peptide Transporter Activity Peptide-transporting ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity ADP Binding TAP1 Binding TAP2 Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Metabolic Process Peptide Transport Intracellular Transport Of Viral Protein In Host Cell Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Transmembrane Transport
Pathways		Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS		Nephropathy ( 21399633)
Protein-protein Interactions		12 interactors: ESR1 HLA-F HLA-G KRTAP4-12 MDFI MUL1 PDIA3 PSMB5 PSMB8 TAP2 TAPBP TDP2
Entrez ID		6890
HPRD ID		01359
Ensembl ID		ENSG00000168394
Uniprot IDs		F5H648 Q03518
PDB IDs		1JJ7
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Positive Regulation Of Signal Transduction Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Response To Stress Cellular Response To Stress Signal Transduction Negative Regulation Of Signal Transduction Signaling Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transferase Activity Cell Communication Negative Regulation Of Signaling Activation Of JUN Kinase Activity Response To Stimulus Regulation Of Apoptotic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Stimulus Regulation Of Wnt Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Catalytic Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Cell Death Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of JUN Kinase Activity Peptide Antigen Stabilization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Modification Process Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of JUN Kinase Activity
Tagcloud ?		activates acts blocks contain crossover crossovers demonstrating dominan ecs element gamma gas hela homodimers ifn isre jak1 jaks janus p48 permits phosphatase shp ss stat1 stat1alpha stat2 transporter tyk