TAP1 and TAPBP

Number of citations of the paper that reports this interaction (PMID 12213826)
11

Data Source:
HPRD (in vitro, in vivo)

		TAP1	TAPBP
Gene Name		transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	TAP binding protein (tapasin)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane TAP Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane MHC Class I Peptide Loading Complex TAP Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding ATP Binding Peptide Transporter Activity Peptide-transporting ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity ADP Binding TAP1 Binding TAP2 Binding	Protein Binding Peptide Antigen-transporting ATPase Activity MHC Class I Protein Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding Unfolded Protein Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Metabolic Process Peptide Transport Intracellular Transport Of Viral Protein In Host Cell Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Transmembrane Transport	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Complex Assembly Retrograde Vesicle-mediated Transport, Golgi To ER Immune Response Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Amide Transport Peptide Antigen Stabilization
Pathways		Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS		Nephropathy ( 21399633)
Protein-Protein Interactions		12 interactors: ESR1 HLA-F HLA-G KRTAP4-12 MDFI MUL1 PDIA3 PSMB5 PSMB8 TAP2 TAPBP TDP2	8 interactors: CALR COPB1 COPG1 COPG2 HLA-A HLA-C TAP1 TAP2
Entrez ID		6890	6892
HPRD ID		01359	09061
Ensembl ID		ENSG00000168394	ENSG00000231925
Uniprot IDs		F5H648 Q03518	O15533
PDB IDs		1JJ7	3F8U
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Positive Regulation Of Signal Transduction Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Response To Stress Cellular Response To Stress Signal Transduction Negative Regulation Of Signal Transduction Signaling Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transferase Activity Cell Communication Negative Regulation Of Signaling Activation Of JUN Kinase Activity Response To Stimulus Regulation Of Apoptotic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Stimulus Regulation Of Wnt Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Catalytic Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Cell Death Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of JUN Kinase Activity Peptide Antigen Stabilization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Modification Process Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of JUN Kinase Activity	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Intracellular Protein Transport Cytosol To ER Transport Retrograde Vesicle-mediated Transport, Golgi To ER Viral Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Intracellular Transport Of Viral Protein In Host Cell Cellular Protein Localization Protein Transport Establishment Of Protein Localization Intracellular Transport COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Protein Localization Establishment Of Localization In Cell Golgi Vesicle Budding Cellular Localization Intracellular Transport Of Virus Vesicle Targeting, To, From Or Within Golgi Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Golgi Vesicle Transport Localization Within Membrane Vesicle Targeting Positive Regulation Of Immune System Process Intra-Golgi Vesicle-mediated Transport Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Immune System Process Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Leukocyte Mediated Cytotoxicity Membrane Budding Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Peptide Antigen Assembly With MHC Class I Protein Complex Response To Type I Interferon Peptide Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Immune System Process Interaction With Host Positive Regulation Of Memory T Cell Activation Positive Regulation Of Adaptive Immune Response Cellular Response To Interferon-gamma
Tagcloud ?		activates acts blocks contain crossover crossovers demonstrating dominan ecs element gamma gas hela homodimers ifn isre jak1 jaks janus p48 permits phosphatase shp ss stat1 stat1alpha stat2 transporter tyk	african c3ar1 chabaudi cope demonstration falciparum fcgr3b highlighted hosts implicate implicating interplay lrrc25 malaria mapped mounted noncoding plasmodium polygenic rad21 responders retn sco1 signature slc39a8 slc3a2 transcriptomes validated west
Tagcloud (Difference) ?		activates acts blocks contain crossover crossovers demonstrating dominan ecs element gamma gas hela homodimers ifn isre jak1 jaks janus p48 permits phosphatase shp ss stat1 stat1alpha stat2 transporter tyk	african c3ar1 chabaudi cope demonstration falciparum fcgr3b highlighted hosts implicate implicating interplay lrrc25 malaria mapped mounted noncoding plasmodium polygenic rad21 responders retn sco1 signature slc39a8 slc3a2 transcriptomes validated west
Tagcloud (Intersection) ?