JAM2 and NME3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		JAM2	NME3
Description		junctional adhesion molecule 2	NME/NM23 nucleoside diphosphate kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cell Surface Membrane Somatodendritic Compartment Cell-cell Contact Zone Tight Junction Anchoring Junction Protein Complex Involved In Cell Adhesion	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Membrane Ciliary Basal Body Cell Projection
	Molecular Function	Integrin Binding Protein Binding	Nucleotide Binding Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity GDP Binding CAMP Binding ADP Binding Metal Ion Binding Phosphatidic Acid Binding Mitochondrion-mitochondrion Outer Membrane Tether Activity
	Biological Process	Leukocyte Cell-cell Adhesion Spermatid Development Negative Regulation Of Myelination Maintenance Of Blood-brain Barrier Cellular Extravasation Leukocyte Tethering Or Rolling Lymphocyte Aggregation Hematopoietic Stem Cell Migration To Bone Marrow Cell-cell Adhesion Positive Regulation Of Lymphocyte Migration	GTP Biosynthetic Process UTP Biosynthetic Process DTTP Biosynthetic Process CTP Biosynthetic Process DNA Repair Apoptotic Process Mitochondrial Fusion Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Protein Hexamerization Mitochondrial Outer Membrane Fusion
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions	Interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Cognitive performance ( 19734545) Longitudinal change in brain amyloid plaque burden ( 26268530) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: CSNK1A1L F2RL2 GPR20 JAM3 NME3 PICK1 SOX8 TDP2 TJP1 YBX1	13 interacting genes: APP DESI1 FXR1 FXR2 HTR2A JAM2 NME1 NME2 SGTA SGTB UBQLN1 UBQLN2 UBQLN4
Entrez ID		58494	4832
HPRD ID		06041	03488
Ensembl ID		ENSG00000154721	ENSG00000103024
Uniprot IDs		P57087	Q13232
PDB IDs			1ZS6 8QVY 8QVZ 8QW0 8QW1 8QW2 8QW3
Enriched GO Terms of Interacting Partners?		Mitochondrial Outer Membrane Fusion Maintenance Of Blood-brain Barrier Cell Development Adherens Junction Organization Tight Junction 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Cellular Component Maintenance Proteinase-activated Receptor Activity Regulation Of Biological Quality Thrombin-activated Receptor Activity Regulation Of Hormone Levels DTTP Biosynthetic Process Mitochondrion-mitochondrion Outer Membrane Tether Activity C5-methylcytidine-containing RNA Reader Activity TRNA Transport Single-stranded DNA Binding Histone Pre-mRNA 3'end Processing Complex MiRNA Transport CRD-mediated MRNA Stability Complex Protein Localization To Bicellular Tight Junction Negative Regulation Of Cytoskeleton Organization Cell-cell Junction Assembly Epithelial Cell Development Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Protein Localization To Cell Junction Positive Regulation Of Blood-brain Barrier Permeability Regulation Of Actin Filament-based Process Adherens Junction Maintenance Protein Localization To Adherens Junction Bicellular Tight Junction Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Membrane Curvature Sensor Activity Negative Regulation Of Photoreceptor Cell Differentiation Metanephric Tubule Formation Renal Vesicle Induction Metanephric Nephron Tubule Formation Astrocyte Fate Commitment Protein Complex Involved In Cell Adhesion Positive Regulation Of Monocyte Extravasation Negative Regulation Of Integrin Activation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Supramolecular Fiber Organization Regulation Of Insulin Secretion Pyrimidine Deoxyribonucleotide Biosynthetic Process Ameloblast Differentiation Ureter Morphogenesis	Identical Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress ITP Biosynthetic Process Protein Histidine Kinase Activity TRC Complex Regulation Of ERAD Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Protein Metabolic Process ITP Metabolic Process Polyubiquitin Modification-dependent Protein Binding Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Presynapse Regulation Of Cellular Response To Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Autophagosome Negative Regulation Of Long-term Synaptic Potentiation CTP Biosynthetic Process CTP Metabolic Process Regulation Of Primary Metabolic Process ERAD Pathway Nucleoside Diphosphate Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Translation Regulator Activity Perinuclear Region Of Cytoplasm GTP Metabolic Process Positive Regulation Of Glycolytic Process Pyrimidine Ribonucleotide Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Dentate Gyrus Development Protein Targeting To ER Pyrimidine Nucleotide Biosynthetic Process Cytoplasmic Vesicle Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Differentiation
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