JAM2

Description		junctional adhesion molecule 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cell Surface Membrane Somatodendritic Compartment Cell-cell Contact Zone Tight Junction Anchoring Junction Protein Complex Involved In Cell Adhesion
	Molecular Function	Integrin Binding Protein Binding
	Biological Process	Leukocyte Cell-cell Adhesion Spermatid Development Negative Regulation Of Myelination Maintenance Of Blood-brain Barrier Cellular Extravasation Leukocyte Tethering Or Rolling Lymphocyte Aggregation Hematopoietic Stem Cell Migration To Bone Marrow Cell-cell Adhesion Positive Regulation Of Lymphocyte Migration
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions
Drugs
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Cognitive performance ( 19734545) Longitudinal change in brain amyloid plaque burden ( 26268530) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: CSNK1A1L F2RL2 GPR20 JAM3 NME3 PICK1 SOX8 TDP2 TJP1 YBX1
Entrez ID		58494
HPRD ID		06041
Ensembl ID		ENSG00000154721
Uniprot IDs		P57087
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrial Outer Membrane Fusion Maintenance Of Blood-brain Barrier Cell Development Adherens Junction Organization Tight Junction 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Cellular Component Maintenance Proteinase-activated Receptor Activity Regulation Of Biological Quality Thrombin-activated Receptor Activity Regulation Of Hormone Levels DTTP Biosynthetic Process Mitochondrion-mitochondrion Outer Membrane Tether Activity C5-methylcytidine-containing RNA Reader Activity TRNA Transport Single-stranded DNA Binding Histone Pre-mRNA 3'end Processing Complex MiRNA Transport CRD-mediated MRNA Stability Complex Protein Localization To Bicellular Tight Junction Negative Regulation Of Cytoskeleton Organization Cell-cell Junction Assembly Epithelial Cell Development Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Protein Localization To Cell Junction Positive Regulation Of Blood-brain Barrier Permeability Regulation Of Actin Filament-based Process Adherens Junction Maintenance Protein Localization To Adherens Junction Bicellular Tight Junction Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Membrane Curvature Sensor Activity Negative Regulation Of Photoreceptor Cell Differentiation Metanephric Tubule Formation Renal Vesicle Induction Metanephric Nephron Tubule Formation Astrocyte Fate Commitment Protein Complex Involved In Cell Adhesion Positive Regulation Of Monocyte Extravasation Negative Regulation Of Integrin Activation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Supramolecular Fiber Organization Regulation Of Insulin Secretion Pyrimidine Deoxyribonucleotide Biosynthetic Process Ameloblast Differentiation Ureter Morphogenesis
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