JAM2 and CSNK1A1L

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		JAM2	CSNK1A1L
Name		junctional adhesion molecule 2	casein kinase 1 alpha 1 like
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cell Surface Membrane Somatodendritic Compartment Cell-cell Contact Zone Tight Junction Anchoring Junction Protein Complex Involved In Cell Adhesion	Nucleus Cytoplasm
	Molecular Function	Integrin Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Leukocyte Cell-cell Adhesion Spermatid Development Negative Regulation Of Myelination Maintenance Of Blood-brain Barrier Cellular Extravasation Leukocyte Tethering Or Rolling Lymphocyte Aggregation Hematopoietic Stem Cell Migration To Bone Marrow Cell-cell Adhesion Positive Regulation Of Lymphocyte Migration	Signal Transduction Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions	None
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Cognitive performance ( 19734545 ) Longitudinal change in brain amyloid plaque burden ( 26268530 ) Metabolite levels ( 23823483 )	Adiponectin levels in pregnancy ( 28317342 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Palmitoleic acid (16:1n-7) levels ( 23362303 )
Interacting Genes		10 interacting genes: CSNK1A1L F2RL2 GPR20 JAM3 NME3 PICK1 SOX8 TDP2 TJP1 YBX1	5 interacting genes: CEACAM3 CEBPE JAM2 TNFRSF1A TNFRSF1B
Entrez ID		58494	122011
HPRD ID		06041	13095
Ensembl ID		ENSG00000154721	ENSG00000180138
Uniprot IDs		P57087	Q8N752
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Mitochondrial Outer Membrane Fusion Maintenance Of Blood-brain Barrier Cell Development Adherens Junction Organization Tight Junction 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Cellular Component Maintenance Proteinase-activated Receptor Activity Regulation Of Biological Quality Thrombin-activated Receptor Activity Regulation Of Hormone Levels DTTP Biosynthetic Process Mitochondrion-mitochondrion Outer Membrane Tether Activity C5-methylcytidine-containing RNA Reader Activity TRNA Transport Single-stranded DNA Binding Histone Pre-mRNA 3'end Processing Complex MiRNA Transport CRD-mediated MRNA Stability Complex Protein Localization To Bicellular Tight Junction Negative Regulation Of Cytoskeleton Organization Cell-cell Junction Assembly Epithelial Cell Development Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Protein Localization To Cell Junction Positive Regulation Of Blood-brain Barrier Permeability Regulation Of Actin Filament-based Process Adherens Junction Maintenance Protein Localization To Adherens Junction Bicellular Tight Junction Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Membrane Curvature Sensor Activity Negative Regulation Of Photoreceptor Cell Differentiation Metanephric Tubule Formation Renal Vesicle Induction Metanephric Nephron Tubule Formation Astrocyte Fate Commitment Protein Complex Involved In Cell Adhesion Positive Regulation Of Monocyte Extravasation Negative Regulation Of Integrin Activation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Supramolecular Fiber Organization Regulation Of Insulin Secretion Pyrimidine Deoxyribonucleotide Biosynthetic Process Ameloblast Differentiation Ureter Morphogenesis	Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Apoptotic Process Involved In Morphogenesis Aortic Valve Development Tumor Necrosis Factor Binding Semi-lunar Valve Development Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Tumor Necrosis Factor Receptor Activity Heart Valve Development Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extracellular Matrix Organization Regulation Of Cardiac Muscle Hypertrophy Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Specific Granule Membrane Regulation Of System Process Extrinsic Apoptotic Signaling Pathway Regulation Of Nervous System Process Cell Surface Negative Regulation Of Secretion By Cell Cellular Response To Lipopolysaccharide Negative Regulation Of Secretion Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response Glial Cell-neuron Signaling Cellular Response To Molecule Of Bacterial Origin Plasma Membrane Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion Lymphocyte Aggregation Membrane Raft Regulation Of Muscle System Process Hematopoietic Stem Cell Migration Negative Regulation Of Defense Response Negative Regulation Of Myelination Negative Regulation Of Multicellular Organismal Process Response To Lipopolysaccharide Leukocyte Aggregation Apoptotic Signaling Pathway Response To Molecule Of Bacterial Origin Response To External Biotic Stimulus Defense Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Membrane Protein Ectodomain Proteolysis DNA-templated Transcription