CASP14

Description		caspase 14
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Keratin Filament
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Epidermis Development Cell Differentiation Keratinization Positive Regulation Of Neuron Apoptotic Process Cornification
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CAPN1 CASP1 CASP10 CASP2 CASP4 CASP8 CDC42 MEOX2 UCHL5
Entrez ID		23581
HPRD ID		05788
Ensembl ID		ENSG00000105141
Uniprot IDs		B2CIS9 P31944
PDB IDs
Enriched GO Terms of Interacting Partners?		Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Peptidase Activity Positive Regulation Of Neuron Apoptotic Process Hydrolase Activity Proteolysis Protein Maturation Execution Phase Of Apoptosis Pyroptotic Inflammatory Response Protein Processing Death Effector Domain Binding Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication NLRP1 Inflammasome Complex Positive Regulation Of Signaling Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Self Proteolysis Canonical Inflammasome Complex Interleukin-18-mediated Signaling Pathway CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Execution Phase Of Apoptosis Protein Autoprocessing Positive Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Mechanical Stimulus Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Macrophage Differentiation Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein-containing Complex Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction
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