CASP14 and UCHL5

Number of citations of the paper that reports this interaction (PMID 21800051)
0

Data Source:
BioGRID (pull down)

		CASP14	UCHL5
Gene Name		caspase 14, apoptosis-related cysteine peptidase	ubiquitin carboxyl-terminal hydrolase L5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Keratin Filament Extracellular Vesicular Exosome	Proteasome Complex Nucleus Cytosol Ino80 Complex
	Molecular Function	Cysteine-type Endopeptidase Activity	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding
	Biological Process	Proteolysis Epidermis Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Keratinization Cornification Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Cannabis dependence ( 21668797)
Protein-Protein Interactions		8 interactors: CAPN1 CASP1 CASP10 CASP2 CASP4 CASP8 MEOX2 UCHL5	96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1
Entrez ID		23581	51377
HPRD ID		05788	10293
Ensembl ID		ENSG00000105141	ENSG00000116750
Uniprot IDs		B2CIS9 P31944	Q9Y5K5
PDB IDs			3A7S 3IHR 3RII 3RIS 3TB3
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Proteolysis Cell Death Death Cellular Response To Mechanical Stimulus Regulation Of Endopeptidase Activity Apoptotic Process Regulation Of Peptidase Activity Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Regulation Of Apoptotic Process Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Processing Regulation Of Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Apoptotic Signaling Pathway Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Mitochondrial Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Cell Death Regulation Of Signal Transduction TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Peptidase Activity Regulation Of Signaling Luteolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Somite Specification Intracellular Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Response To Stress	Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process
Tagcloud ?		abc bcl2af1 bcl2l10 biology casp8 cd70 changed cideb cluster correlate fadd hierarchical hrk igf1r mcl1 needle neoadjuvant pathologic profiling prognosis reflect removed substantially therapeutically tnfrsf25 tnfsf8 tunel valuable
Tagcloud (Difference) ?		abc bcl2af1 bcl2l10 biology casp8 cd70 changed cideb cluster correlate fadd hierarchical hrk igf1r mcl1 needle neoadjuvant pathologic profiling prognosis reflect removed substantially therapeutically tnfrsf25 tnfsf8 tunel valuable
Tagcloud (Intersection) ?