FLG

Gene Name		filaggrin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Intermediate Filament Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding
	Biological Process	Multicellular Organismal Development Keratinocyte Differentiation Establishment Of Skin Barrier
Pathways
Drugs
Diseases
GWAS		Atopic dermatitis ( 21666691) Eating disorders ( 23568457)
Protein-protein Interactions		3 interactors: CSNK2A1 PCSK6 UCHL5
Entrez ID		2312
HPRD ID		15920
Ensembl ID		ENSG00000143631
Uniprot IDs		P20930
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Nerve Growth Factor Production Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Zygotic Determination Of Anterior/posterior Axis, Embryo Nerve Growth Factor Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Regulation Of Protein Catabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Proteolysis Cell Surface Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Morphogenesis Lateral Ventricle Development Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Peptide Hormone Processing Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Brain Morphogenesis Ventricular System Development Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Embryonic Axis Specification Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chaperone-mediated Protein Folding Multicellular Organismal Development Negative Regulation Of Proteasomal Protein Catabolic Process Anterior/posterior Axis Specification Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of BMP Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Midbrain Development
Tagcloud ?		activating adaptor associates autocrine becomes constitutive exchange expected fgf fgfr fibroblast gamma grb2 guanine instead neither nucleotide p90 phospholipase phosphorylated plc ras shc sos src suramin transformed tyrosine v