FLG and PCSK6

Number of citations of the paper that reports this interaction (PubMedID 11380615)
0

Data Source:
HPRD (in vitro)

		FLG	PCSK6
Description		filaggrin	proprotein convertase subtilisin/kexin type 6
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytosol Extracellular Matrix Keratohyalin Granule Cytoplasmic Ribonucleoprotein Granule	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Endomembrane System Membrane Extracellular Matrix
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Skin Epidermis Metal Ion Binding Transition Metal Ion Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Nerve Growth Factor Binding
	Biological Process	Peptide Cross-linking Keratinocyte Differentiation Establishment Of Skin Barrier	Proteolysis Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Plasma Lipoprotein Particle Remodeling
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases		Ichthyosis vulgaris
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 30929738 34103634 32296059 31959851 31619474 31361310) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 21666691 26482879 25574825 23886662) Atopic march ( 26542096) Eating disorders ( 23568457) Eczema ( 31361310) Male-pattern baldness ( 28196072)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)
Interacting Genes		5 interacting genes: CSNK2A1 PCSK6 UBXN7 UCHL5 WEE2-AS1	7 interacting genes: CACNA1A DYRK1A FLG PCSK5 PMCH RCN3 ZNF441
Entrez ID		2312	5046
HPRD ID		15920	01329
Ensembl ID		ENSG00000143631	ENSG00000140479
Uniprot IDs		P20930	A2RQD9 H7BXT3 P29122 Q59H04
PDB IDs		4PCW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Catabolic Process Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo Protein Kinase CK2 Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Pre-mRNA 5'-splice Site Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Aggrephagy Nerve Growth Factor Binding Macromolecule Catabolic Process Regulation Of DNA Repair DNA Recombination MRNA 5'-splice Site Recognition VCP-NPL4-UFD1 AAA ATPase Complex Forebrain Morphogenesis Proteolysis Anterior/posterior Axis Specification, Embryo Double-strand Break Repair Via Classical Nonhomologous End Joining Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Metabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage Lateral Ventricle Development Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis Regulation Of DNA Strand Elongation Ino80 Complex MRNA Methylguanosine-cap Decapping Proteasome Binding U1 SnRNP RNA Decapping Sin3-type Complex Peptidase Activity	Phosphoethanolamine Phosphatase Activity Response To Vitamin B6 Futile Creatine Cycle Phosphoamidase Activity Extracellular Membrane-bounded Organelle Response To Amyloid-beta Cellular Response To Amyloid-beta Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Type 1 Melanin-concentrating Hormone Receptor Binding Negative Regulation Of Synaptic Transmission, Dopaminergic Melanin-concentrating Hormone Activity Neurofilament Cytoskeleton Fast-twitch Skeletal Muscle Fiber Contraction Protein-fructosamine 3-kinase Activity Fructosamine Metabolic Process Protein Deglycation Protein-ribulosamine 3-kinase Activity Fructoselysine Metabolic Process
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