CCP110 and AKAP9

Number of citations of the paper that reports this interaction (PubMedID 16760425)
39

Data Source:
HPRD (in vivo)

		CCP110	AKAP9
Description		centriolar coiled-coil protein 110	A-kinase anchoring protein 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Cilium Protein-containing Complex Cell Projection	Cytoplasm Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Potassium Channel Complex Neuronal Cell Body Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Transmembrane Transporter Binding Molecular Adaptor Activity Potassium Channel Activator Activity
	Biological Process	Centriole Replication Cell Projection Organization Ciliary Basal Body Organization Regulation Of Cytokinesis Positive Regulation Of Cilium Assembly Centrosome Duplication Negative Regulation Of Cilium Assembly	Microtubule Nucleation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Microtubule Polymerization Protein-containing Complex Localization Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Golgi Organization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Ub-specific processing proteases AURKA Activation by TPX2 RHOV GTPase cycle	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF1 fusions AURKA Activation by TPX2
Drugs
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS			Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Appendicular lean mass ( 33097823) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Red blood cell count ( 32888494)
Interacting Genes		14 interacting genes: AKAP9 CALM1 CALM3 CDK1 CDK2 CEP97 CETN1 CETN2 DCAF1 PCNT PNMA1 TFIP11 USP33 USP7	85 interacting genes: ABI2 BEX2 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCDC116 CCDC146 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 CTNNA3 DVL2 FAM90A1 FMR1 FNBP1 FXR2 GLIS2 GPC4 GRIN1 GTSE1 HDDC3 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 LMO1 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 RSRC2 SAMD3 SCNM1 SF3B2 SLAIN1 SNF8 SNRPB SSX2 SSX3 SSX5 SUV39H2 TACC3 TCEANC TDP2 TENT5B THAP1 THOC1 TLX3 TNIK TRIP10 TSG101 TSNAX TUBGCP3 TULP3 USHBP1 USO1 VPS9D1 WAC YWHAE
Entrez ID		9738	10142
HPRD ID		10848	04921
Ensembl ID		ENSG00000103540	ENSG00000127914
Uniprot IDs		O43303	A0A2R8Y590 Q5GIA7 Q6PJH3 Q99996
PDB IDs
Enriched GO Terms of Interacting Partners?		Centrosome Cytoskeleton G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Negative Regulation Of High Voltage-gated Calcium Channel Activity Microtubule Organizing Center Organization Centriole Replication Cytoplasm Regulation Of Cardiac Muscle Cell Action Potential Cyclin-dependent Protein Kinase Activity Centriole Assembly VCB Complex Mitotic Cell Cycle Phase Transition Spindle Microtubule Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Cell Cycle Phase Transition Histone Kinase Activity Centriole Protection From Non-homologous End Joining At Telomere Heterotrimeric G-protein Binding Regulation Of Action Potential Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cell Cycle Process DNA Metabolic Process Microtubule Cytoskeleton Organization Microtubule-based Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Voltage-gated Potassium Channel Complex Post-translational Protein Modification Titin Binding Regulation Of Cytokinesis Telomere Maintenance In Response To DNA Damage Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Organelle Organization Microtubule Organizing Center Protein Deubiquitination Regulation Of Cell Communication By Electrical Coupling Regulation Of Heart Rate Protein Phosphatase Activator Activity Calyx Of Held Centrosome Duplication Protein Modification By Small Protein Removal G-protein Beta/gamma-subunit Complex Binding Regulation Of Cell Cycle Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion	Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Cytoskeleton Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transporter Activity Cytoplasm Centrosome Nucleus Microtubule Nucleation Negative Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate Adenylate Cyclase Activator Activity Negative Regulation Of Calcium Ion Transmembrane Transport Protein Binding Negative Regulation Of Transmembrane Transport Spindle Microtubule Transporter Inhibitor Activity Microtubule-based Process Regulation Of Cardiac Muscle Contraction Regulation Of Cytokinesis Regulation Of Cell Cycle Transmembrane Transporter Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transport Nucleoplasm Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Metal Ion Transport Regulation Of Action Potential Regulation Of Striated Muscle Contraction Microtubule Cytoskeleton Organization Regulation Of Calcium Ion Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Domain Specific Binding Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Ubiquitin Protein Ligase Binding Spindle Titin Binding Calcium Channel Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate By Cardiac Conduction Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Regulation Of Transmembrane Transporter Activity
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