CCP110 and CETN2

Number of citations: 39 (PubMedID 16760425)
Data Source: HPRD (in vivo, two hybrid)

		CCP110	CETN2
Name		centriolar coiled-coil protein 110	centrin 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Cilium Protein-containing Complex Cell Projection	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Nuclear Pore Nuclear Basket Apical Part Of Cell Transcription Export Complex 2 XPC Complex Glial Cell Projection 9+2 Motile Cilium
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Microtubule Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Metal Ion Binding
	Biological Process	Centriole Replication Cell Projection Organization Ciliary Basal Body Organization Regulation Of Cytokinesis Positive Regulation Of Cilium Assembly Centrosome Duplication Negative Regulation Of Cilium Assembly	Microtubule Cytoskeleton Organization Mitotic Cell Cycle DNA Repair Nucleotide-excision Repair DNA Damage Response Centriole Replication Spermatogenesis Protein Transport Regulation Of Cytokinesis MRNA Transport Cell Division
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Ub-specific processing proteases AURKA Activation by TPX2 RHOV GTPase cycle	Regulation of PLK1 Activity at G2/M Transition SUMOylation of DNA damage response and repair proteins Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER AURKA Activation by TPX2
GWAS		No GWAS studies recorded	Serum alkaline phosphatase levels ( 33339817 )
Interacting Genes		14 interacting genes: AKAP9 CALM1 CALM3 CDK1 CDK2 CEP97 CETN1 CETN2 DCAF1 PCNT PNMA1 TFIP11 USP33 USP7	7 interacting genes: ARSA CCP110 PNMA5 PRMT6 SFI1 UBC XPC
Entrez ID		9738	1069
HPRD ID		10848	02051
Ensembl ID		ENSG00000103540	ENSG00000147400
Uniprot IDs		O43303	P41208
PDB IDs		Not available	1M39 1ZMZ 2A4J 2GGM 2K2I 2OBH 8EBS 8EBT 8EBV 8EBW 8EBX 8J07
GO Terms Enriched among Interactors		Centrosome Cytoskeleton G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Negative Regulation Of High Voltage-gated Calcium Channel Activity Microtubule Organizing Center Organization Centriole Replication Cytoplasm Regulation Of Cardiac Muscle Cell Action Potential Cyclin-dependent Protein Kinase Activity Centriole Assembly VCB Complex Mitotic Cell Cycle Phase Transition Spindle Microtubule Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Cell Cycle Phase Transition Histone Kinase Activity Centriole Protection From Non-homologous End Joining At Telomere Heterotrimeric G-protein Binding Regulation Of Action Potential Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cell Cycle Process DNA Metabolic Process Microtubule Cytoskeleton Organization Microtubule-based Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Voltage-gated Potassium Channel Complex Post-translational Protein Modification Titin Binding Regulation Of Cytokinesis Telomere Maintenance In Response To DNA Damage Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Organelle Organization Microtubule Organizing Center Protein Deubiquitination Regulation Of Cell Communication By Electrical Coupling Regulation Of Heart Rate Protein Phosphatase Activator Activity Calyx Of Held Centrosome Duplication Protein Modification By Small Protein Removal G-protein Beta/gamma-subunit Complex Binding Regulation Of Cell Cycle Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion	None