NIPBL and DBN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		NIPBL	DBN1
Gene Name		Nipped-B homolog (Drosophila)	drebrin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SMC Loading Complex Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Gap Junction Cell Cortex Actin Cytoskeleton Dendrite Actomyosin
	Molecular Function	Chromatin Binding Protein Binding Protein C-terminus Binding Mediator Complex Binding Histone Deacetylase Binding Protein N-terminus Binding Chromo Shadow Domain Binding	Actin Binding Protein Binding Profilin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Cellular Response To DNA Damage Stimulus Mitotic Sister Chromatid Cohesion Brain Development Sensory Perception Of Sound Stem Cell Maintenance Positive Regulation Of Histone Deacetylation Maintenance Of Mitotic Sister Chromatid Cohesion Cellular Protein Localization Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gall Bladder Development Uterus Morphogenesis Cellular Response To X-ray	Actin Filament Organization Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Maintenance Of Protein Location In Cell Regulation Of Neuronal Synaptic Plasticity Regulation Of Dendrite Development Neural Precursor Cell Proliferation
Pathways		Mitotic Telophase/Cytokinesis Cohesin Loading onto Chromatin Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		8 interactors: CBX3 CBX5 CDK6 DBN1 HINFP MAU2 PRSS23 SP100	24 interactors: ACD BAK1 BTRC CDK2AP2 DNMBP DUSP23 FHL1 HOMER2 MAP1LC3B MAPK6 MEST NIPBL NUDT21 NUDT3 PFN1 POT1 SNUPN SUPT5H TAB1 TERF1 TINF2 TPT1 UBE2D3 ZNF598
Entrez ID		25836	1627
HPRD ID		10560	00545
Ensembl ID		ENSG00000164190	ENSG00000113758
Uniprot IDs		Q6KC79	F8W9Z3 Q16643
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Dedifferentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Fas Signaling Pathway Cell Communication By Chemical Coupling Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Maintenance Of Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Chromatin Remodeling Negative Regulation Of Protein Export From Nucleus Negative Regulation Of Cellular Senescence Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Chromosome Organization Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Hematopoietic Stem Cell Differentiation Cell Communication By Electrical Coupling Negative Regulation Of Cell Aging Mitotic Sister Chromatid Cohesion Dentate Gyrus Development Type B Pancreatic Cell Development Negative Regulation Of Viral Transcription Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Astrocyte Development Type B Pancreatic Cell Differentiation Cell Cycle Lateral Ventricle Development Enteroendocrine Cell Differentiation Cell Division	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of Chromosome Organization Positive Regulation Of Organelle Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Regulation Of Organelle Organization Negative Regulation Of Biosynthetic Process Positive Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Cellular Metabolic Process Homeostatic Process Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Regulation Of Cellular Component Organization Negative Regulation Of DNA Biosynthetic Process Chromosome Organization Positive Regulation Of Cellular Metabolic Process DNA Metabolic Process Positive Regulation Of Catalytic Activity Protein Localization To Chromosome Tube Development Positive Regulation Of Metabolic Process Tube Morphogenesis Limb Morphogenesis Regulation Of Catalytic Activity Limb Development Positive Regulation Of Viral Transcription Negative Regulation Of Protein ADP-ribosylation SnRNA Import Into Nucleus Diphosphoinositol Polyphosphate Catabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Diadenosine Polyphosphate Catabolic Process Organelle Organization Cellular Component Assembly
Tagcloud ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem novo partitioning rad21 recursive separase smc1a smc3 undetected
Tagcloud (Difference) ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem novo partitioning rad21 recursive separase smc1a smc3 undetected
Tagcloud (Intersection) ?