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NIPBL and PRSS23
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
NIPBL
PRSS23
Description
NIPBL cohesin loading factor
serine protease 23
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Chromosome
Cytosol
Integrator Complex
SMC Loading Complex
Extracellular Exosome
Scc2-Scc4 Cohesin Loading Complex
Extracellular Region
Nucleus
Endoplasmic Reticulum Lumen
Extracellular Exosome
Molecular Function
Chromatin Binding
Transcription Corepressor Activity
Protein Binding
Mediator Complex Binding
Histone Deacetylase Binding
Cohesin Loader Activity
Chromo Shadow Domain Binding
Promoter-specific Chromatin Binding
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Biological Process
Mitotic Sister Chromatid Segregation
Negative Regulation Of Transcription By RNA Polymerase II
Metanephros Development
Heart Morphogenesis
Outflow Tract Morphogenesis
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Mitotic Sister Chromatid Cohesion
Brain Development
Heart Development
Sensory Perception Of Sound
Intracellular Protein Localization
Regulation Of Gene Expression
Establishment Of Mitotic Sister Chromatid Cohesion
Maintenance Of Mitotic Sister Chromatid Cohesion
Somatic Stem Cell Population Maintenance
Embryonic Forelimb Morphogenesis
Forelimb Morphogenesis
External Genitalia Morphogenesis
Positive Regulation Of Multicellular Organism Growth
Ear Morphogenesis
Regulation Of Hair Cycle
Fat Cell Differentiation
Positive Regulation Of Ossification
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Embryonic Digestive Tract Morphogenesis
Embryonic Organ Morphogenesis
Digestive Tract Development
Developmental Growth
Eye Morphogenesis
Regulation Of Developmental Growth
Embryonic Cranial Skeleton Morphogenesis
Embryonic Viscerocranium Morphogenesis
Cognition
Face Morphogenesis
Gallbladder Development
Uterus Morphogenesis
Establishment Of Protein Localization To Chromatin
Cellular Response To X-ray
Chromatin Looping
Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Positive Regulation Of Neuron Migration
Proteolysis
Pathways
Cohesin Loading onto Chromatin
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Drugs
Diseases
Cornelia de Lange syndrome (CdLS)
GWAS
Height (
25282103
28552196
31562340
)
Malaria (
31844061
)
Meat-related diet (
32066663
)
Obesity-related traits (
23251661
)
Weight (
28552196
)
Blood urea nitrogen levels (
31152163
)
Chronic obstructive pulmonary disease (
30804561
)
FEV1 (
30804560
)
Heel bone mineral density (
28869591
30598549
)
Intraocular pressure (
29617998
29785010
)
Lung function (FEV1) (
28166213
)
Lung function (FEV1/FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Interacting Genes
11 interacting genes:
CBX5
CDK6
DBN1
DSCR9
HINFP
MAP1LC3C
PCNA
PCNT
PRSS23
SP100
SUMO2
27 interacting genes:
ACTG1
APP
B2M
CHP1
EFNA3
FXR1
GATD1
GRK6
HSPA4
MAPK8IP2
NCAPD3
NIPBL
NOC4L
ODF2L
PDPK1
PHF23
PPIA
RACGAP1
RECQL4
RPL4P5
SEC11C
SHMT1
SLC25A6
TCF12
TMEM222
TRAPPC4
UBC
Entrez ID
25836
11098
HPRD ID
10560
07149
Ensembl ID
ENSG00000164190
ENSG00000150687
Uniprot IDs
A0A590UJS4
Q6KC79
O95084
PDB IDs
6WG3
6WGE
7W1M
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
Generation Of Neurons
PML Body
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Response To Stress
Postsynaptic Cytosol
Chromosome, Telomeric Region
Cyclin-dependent Protein Kinase Holoenzyme Complex
Cyclin D2-CDK6 Complex
Maintenance Of Protein Location In Cell
PCNA Complex
Replisome
Negative Regulation Of DNA-templated Transcription
G1/S Transition Of Mitotic Cell Cycle
Cyclin D3-CDK6 Complex
Cyclin D1-CDK6 Complex
Negative Regulation Of RNA Biosynthetic Process
FBXO Family Protein Binding
Cell Communication By Chemical Coupling
Maintenance Of Protein Location
Maintenance Of Location In Cell
Maintenance Of Location
PCNA-p21 Complex
DNA Polymerase Processivity Factor Activity
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
Cell Cycle G1/S Phase Transition
Negative Regulation Of RNA Metabolic Process
Mitotic Telomere Maintenance Via Semi-conservative Replication
Dinucleotide Insertion Or Deletion Binding
Telomere Maintenance
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Neurogenesis
Positive Regulation Of Receptor Localization To Synapse
Positive Regulation Of Deoxyribonuclease Activity
Leading Strand Elongation
Regulation Of Fas Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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