TIMELESS and CRY2

Number of citations of the paper that reports this interaction (PubMedID 15798197)
43

Data Source:
HPRD (in vivo)

		TIMELESS	CRY2
Description		timeless circadian regulator	cryptochrome circadian regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Replication Fork Protection Complex Site Of Double-strand Break	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Speck Cry-Per Complex
	Molecular Function	DNA Binding Protein Binding Enzyme Activator Activity Identical Protein Binding	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Phosphatase Inhibitor Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding FAD Binding
	Biological Process	DNA Replication Checkpoint Signaling Morphogenesis Of An Epithelium DNA Repair DNA Damage Response Circadian Rhythm Detection Of Abiotic Stimulus Lung Development Replication Fork Processing Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Replication Fork Arrest Cell Cycle Phase Transition Negative Regulation Of DNA-templated Transcription Rhythmic Process Branching Morphogenesis Of An Epithelial Tube Cell Division Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Bleomycin Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Protein Import Into Nucleus Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Response To Insulin Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways		Processing of DNA double-strand break ends	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		Axial length ( 24144296) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Glycemic traits (pleiotropy) ( 31021400) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)
Interacting Genes		12 interacting genes: CHEK1 CLSPN CRY1 CRY2 PCBD1 PER1 PER2 PLK1 TF TIPIN WEE2-AS1 ZSCAN1	53 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 CYSRT1 DELEC1 EZH2 FBXL21P FBXL3 KLHL6 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP19-6 KRTAP4-2 KRTAP5-1 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-8 LMNA MID1 MTUS2 NADK NBPF19 NOTCH2NLA NPAS2 PDE9A PER1 PER2 PER3 PICK1 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGER4 SBK3 SDCBP2 STK11 TIMELESS TRAF1 TRAF2 TTC1 VWC2 XRN2 ZBTB42
Entrez ID		8914	1408
HPRD ID		04864	07226
Ensembl ID		ENSG00000111602	ENSG00000121671
Uniprot IDs		Q9UNS1	A0A0D2X7Z3 A2I2P1 Q49AN0
PDB IDs		4XHT 4XHU 4XHW 5MQI 6T9Q 6TAZ 7PFO 7PLO 8B9D
Enriched GO Terms of Interacting Partners?		Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Signal Transduction In Response To DNA Damage Negative Regulation Of Circadian Rhythm Mitotic DNA Damage Checkpoint Signaling Circadian Regulation Of Gene Expression Mitotic DNA Integrity Checkpoint Signaling Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity DNA Damage Checkpoint Signaling Regulation Of Circadian Rhythm Cry-Per Complex Mitotic G2 DNA Damage Checkpoint Signaling Response To Light Stimulus Circadian Rhythm Negative Regulation Of Glucocorticoid Secretion Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Mitotic G2/M Transition Checkpoint DNA Damage Response Response To Blue Light Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Photoreceptor Activity Anaphase-promoting Complex Binding Rhythmic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Mitotic Nuclear Membrane Disassembly Negative Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Kinase Binding Nuclear Membrane Disassembly Regulation Of G2/M Transition Of Mitotic Cell Cycle Membrane Disassembly Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Metabolic Process DNA Replication Checkpoint Signaling Regulation Of Cell Cycle Process DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process	Intermediate Filament Photoperiodism Regulation Of Circadian Rhythm Rhythmic Process Entrainment Of Circadian Clock By Photoperiod Keratin Filament Entrainment Of Circadian Clock Cytosol Circadian Regulation Of Gene Expression Circadian Rhythm Transcription Corepressor Binding Identical Protein Binding Response To Light Stimulus Response To Radiation Protein Phosphatase Type 2A Complex CLOCK-BMAL Transcription Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Binding Protein Phosphatase Regulator Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Thioesterase Binding Meiotic Sister Chromatid Cohesion E-box Binding Response To Redox State G1 To G0 Transition
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