DENND4A and C1QTNF9

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		DENND4A	C1QTNF9
Description		DENN domain containing 4A	C1q and TNF related 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoplasmic Vesicle	Extracellular Region Collagen Trimer
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	Hormone Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Rab Protein Signal Transduction	Signal Transduction
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Logical memory (delayed recall) in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 20139978 27863252 29403010) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		7 interacting genes: C1QTNF9 CEBPE CLK1 PCBD1 SERTAD1 TLX3 YWHAG	17 interacting genes: ACTC1 AMPD1 APPL1 CAPN3 DENND4A DST EIF4G2 GYG1 LARP4B MYBPC1 MYOM1 NAP1L1 NDUFS1 RDX TTN UTRN ZNF407
Entrez ID		10260	338872
HPRD ID		02662	14659
Ensembl ID		ENSG00000174485	ENSG00000240654
Uniprot IDs		A0A0U1RR27 A0A7I2RAZ6 Q05C90 Q7Z401	P0C862
PDB IDs
Enriched GO Terms of Interacting Partners?		4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine	Actomyosin Structure Organization Structural Constituent Of Muscle Sarcomere Organization Protein Kinase A Signaling M Band Myofibril Assembly Skeletal Muscle Thin Filament Assembly Actin Cytoskeleton Organization Actin Filament-based Process Filopodium Titin Binding Cardiac Myofibril Assembly Actin-myosin Filament Sliding Actin Cytoskeleton Myosin Filament Muscle Organ Development Cytoskeleton Organization I Band Myosin Binding Z Disc Muscle Structure Development Actin Binding Protein Homodimerization Activity Actin-mediated Cell Contraction Structural Molecule Activity Positive Regulation Of Gene Expression Muscle Contraction Cardiac Muscle Contraction Cytosol Calcium-dependent Self Proteolysis Positive Regulation Of Transport Myofibril T-tubule Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Sarcomere Muscle System Process Actin Filament-based Movement Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process H Zone Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Glycogenin Glucosyltransferase Activity Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Positive Regulation Of Macropinocytosis Cytoskeletal Protein Binding Positive Regulation Of Biosynthetic Process Muscle Tissue Morphogenesis
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