PARD6B and CEP76

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		PARD6B	CEP76
Description		par-6 family cell polarity regulator beta	centrosomal protein 76
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Apical Part Of Cell Extracellular Exosome Tight Junction Anchoring Junction PAR Polarity Complex	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell-cell Junction Assembly Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Axonogenesis Regulation Of Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Regulation Of Cellular Localization Protein-containing Complex Assembly	Regulation Of Centriole Replication
Pathways		Tight junction interactions RHOV GTPase cycle	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Bipolar disorder ( 21771265)
Interacting Genes		34 interacting genes: APP ARAP3 BANP CDC42 CDCA4 CEP76 FRMD6 GMCL1 GOLGA2 HSF2BP HTRA1 MAGOHB OGT PALS1 PARD3 PARD3B PARD6A PNMA1 PRKCG PRKCI PRKCZ RAC1 RASSF3 RHOJ RHOQ SIAH1 TCP10L3 TRIB3 TRIM35 WDR83 YWHAB YWHAH YWHAZ ZSCAN4	105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85
Entrez ID		84612	79959
HPRD ID		18703	12694
Ensembl ID		ENSG00000124171	ENSG00000101624
Uniprot IDs		Q9BYG5	B4DP81 Q8TAP6
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity PAR Polarity Complex Establishment Of Cell Polarity Bicellular Tight Junction Apical Junction Complex Tight Junction GBD Domain Binding Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity GTP-dependent Protein Binding Cytoskeleton Organization Intracellular Protein Localization Response To Insulin Cell-cell Junction Organization Protein Kinase Binding Cell Cortex Response To Peptide Hormone Supramolecular Fiber Organization Cellular Response To Insulin Stimulus Regulation Of Synaptic Plasticity Phosphoserine Residue Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Apical Plasma Membrane G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Identical Protein Binding Intracellular Signal Transduction Establishment Of Golgi Localization Negative Regulation Of Protein Localization To Nucleus Actin Filament Organization Thioesterase Binding Establishment Of Centrosome Localization Organelle Organization Schmidt-Lanterman Incisure Plasma Membrane Cell Junction Organization Asymmetric Cell Division Regulation Of Synapse Organization Regulation Of Protein Localization Golgi Localization Regulation Of Cell Communication Extracellular Exosome Regulation Of Signaling Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Cellular Response To Peptide Hormone Stimulus Regulation Of Insulin Receptor Signaling Pathway Regulation Of D-glucose Transmembrane Transport Cellular Localization	Protein Binding Nucleus
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