PARD6B and MAGOHB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PARD6B	MAGOHB
Description		par-6 family cell polarity regulator beta	mago homolog B, exon junction complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Apical Part Of Cell Extracellular Exosome Tight Junction Anchoring Junction PAR Polarity Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Exon-exon Junction Complex Neuronal Cell Body U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14
	Molecular Function	Protein Binding	RNA Binding Protein Binding
	Biological Process	Cell-cell Junction Assembly Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Axonogenesis Regulation Of Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Regulation Of Cellular Localization Protein-containing Complex Assembly	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus RNA Splicing Regulation Of MRNA Processing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		Tight junction interactions RHOV GTPase cycle	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Bipolar disorder ( 21771265)
Interacting Genes		34 interacting genes: APP ARAP3 BANP CDC42 CDCA4 CEP76 FRMD6 GMCL1 GOLGA2 HSF2BP HTRA1 MAGOHB OGT PALS1 PARD3 PARD3B PARD6A PNMA1 PRKCG PRKCI PRKCZ RAC1 RASSF3 RHOJ RHOQ SIAH1 TCP10L3 TRIB3 TRIM35 WDR83 YWHAB YWHAH YWHAZ ZSCAN4	74 interacting genes: ADAMTSL4 AMOTL2 BEND7 C18orf54 CALCOCO2 CARD10 CCDC102B CCDC106 CCDC33 CEBPA DVL2 DVL3 EFHC2 FHL5 FXR1 GNPDA2 GOLGA2 GPANK1 HMG20A HSF2BP IHO1 IKZF1 IKZF3 INCA1 KRT40 KRT75 KRTAP1-1 KRTAP13-2 MID2 NDUFB7 PARD6B PAX7 PBX4 PKP2 PRPH PRPSAP1 PTPN21 RBAK RBM8A RBMX REL RUNDC3A SNW1 SPATA6 SPDYE4 STX11 TADA2A TCF4 TERF2 TERF2IP THAP7 TLE5 TRA2A TRA2B TRIM27 TRIM42 YWHAG ZBTB10 ZBTB42 ZFP14 ZFYVE1 ZNF19 ZNF250 ZNF398 ZNF426 ZNF438 ZNF446 ZNF449 ZNF547 ZNF566 ZNF57 ZNF620 ZNF774 ZNF835
Entrez ID		84612	55110
HPRD ID		18703	08544
Ensembl ID		ENSG00000124171	ENSG00000111196
Uniprot IDs		Q9BYG5	F5H6P7 Q96A72
PDB IDs			5XJC 5YZG 6ICZ 6QDV
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity PAR Polarity Complex Establishment Of Cell Polarity Bicellular Tight Junction Apical Junction Complex Tight Junction GBD Domain Binding Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity GTP-dependent Protein Binding Cytoskeleton Organization Intracellular Protein Localization Response To Insulin Cell-cell Junction Organization Protein Kinase Binding Cell Cortex Response To Peptide Hormone Supramolecular Fiber Organization Cellular Response To Insulin Stimulus Regulation Of Synaptic Plasticity Phosphoserine Residue Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Apical Plasma Membrane G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Identical Protein Binding Intracellular Signal Transduction Establishment Of Golgi Localization Negative Regulation Of Protein Localization To Nucleus Actin Filament Organization Thioesterase Binding Establishment Of Centrosome Localization Organelle Organization Schmidt-Lanterman Incisure Plasma Membrane Cell Junction Organization Asymmetric Cell Division Regulation Of Synapse Organization Regulation Of Protein Localization Golgi Localization Regulation Of Cell Communication Extracellular Exosome Regulation Of Signaling Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Cellular Response To Peptide Hormone Stimulus Regulation Of Insulin Receptor Signaling Pathway Regulation Of D-glucose Transmembrane Transport Cellular Localization	Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Primary Metabolic Process Zinc Ion Binding Regulation Of Macromolecule Biosynthetic Process Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleus Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of RNA Splicing Identical Protein Binding Intermediate Filament Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomeric DNA Binding Intermediate Filament Organization Regulation Of MRNA Processing Shelterin Complex Protection From Non-homologous End Joining At Telomere Positive Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Positive Regulation Of Neuron Projection Arborization Positive Regulation Of RNA Metabolic Process Nuclear Telomere Cap Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament G-rich Strand Telomeric DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Localization To Chromosome, Telomeric Region Spliceosomal Complex Regulation Of RNA Splicing Telomere Capping Metal Ion Binding Telomere Maintenance In Response To DNA Damage
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