PARD6B and MPP5

Number of citations of the paper that reports this interaction (PMID 12545177)
108

Data Source:
HPRD (in vitro, in vivo)

		PARD6B	MPP5
Gene Name		par-6 family cell polarity regulator beta	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Tight Junction Cell Cortex Protein Complex Apical Part Of Cell Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Plasma Membrane Tight Junction Endomembrane System Myelin Sheath Adaxonal Region Lateral Loop Schmidt-Lanterman Incisure Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding Protein Domain Specific Binding
	Biological Process	Protein Complex Assembly Cell-cell Junction Assembly Cell Cycle Establishment Or Maintenance Of Cell Polarity Axonogenesis Regulation Of Cell Migration Cell Junction Assembly Cell-cell Junction Organization Cell Division Tight Junction Assembly	Morphogenesis Of An Epithelial Sheet Peripheral Nervous System Myelin Maintenance Myelin Assembly Cell Junction Assembly Protein Localization To Myelin Sheath Abaxonal Region Cell-cell Junction Organization Tight Junction Assembly Establishment Of Protein Localization To Plasma Membrane
Pathways		Cell junction organization Cell-cell junction organization Tight junction interactions	Cell junction organization Cell-cell junction organization Tight junction interactions
Drugs
Diseases
GWAS		Bipolar disorder ( 21771265)
Protein-Protein Interactions		22 interactors: APP CDC42 CEP76 GMCL1 GOLGA2 HTRA1 MPP5 PARD3 PARD3B PARD6A PNMA1 PRKCG PRKCI PRKCZ RAC1 RHOJ RHOQ TCP10 WDR83 YWHAB YWHAH YWHAZ	6 interactors: ARF6 CRB3 INADL LIN7A MPP4 PARD6B
Entrez ID		84612	64398
HPRD ID		18703	09508
Ensembl ID		ENSG00000124171	ENSG00000072415
Uniprot IDs		Q9BYG5	Q658X5 Q8N3R9
PDB IDs			1Y76 3UIT
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Enzyme Linked Receptor Protein Signaling Pathway Tight Junction Assembly Regulation Of Cellular Component Organization Membrane Organization Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apical Junction Assembly Wound Healing Response To Growth Factor Platelet Activation Positive Regulation Of Cell Death Actin Filament-based Process Cellular Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Intracellular Signal Transduction Blood Coagulation Regulation Of Cellular Localization Hemostasis Response To Wounding Cellular Component Assembly Regulation Of Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Protein Localization Cell-cell Junction Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Glucose Import Neurogenesis Positive Regulation Of Glucose Transport Regulation Of Body Fluid Levels Nervous System Development Regulation Of Organelle Organization Actin Cytoskeleton Organization Defense Response Establishment Of Golgi Localization Neuron Development Protein Localization To Membrane Cellular Localization Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Establishment Or Maintenance Of Cell Polarity Protein Localization Regulation Of Glucose Import Positive Regulation Of Mitochondrion Organization	Tight Junction Assembly Apical Junction Assembly Cell-cell Junction Assembly Establishment Or Maintenance Of Cell Polarity Cell Junction Assembly Cell-cell Junction Organization Cellular Component Assembly Protein Localization Protein Localization To Plasma Membrane Protein Localization To Basolateral Plasma Membrane Plasma Membrane Organization Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Myeloid Cell Apoptotic Process Protein Localization To Endosome Maintenance Of Cell Polarity Cellular Protein Localization Protein Localization To Membrane Establishment Of Epithelial Cell Polarity Cell Division Endomembrane System Organization Protein Localization To Cell Surface Protein Localization To Synapse Negative Regulation Of Receptor-mediated Endocytosis Hepatocyte Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Cortical Actin Cytoskeleton Organization Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Ruffle Organization Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Endocytosis Regulation Of Filopodium Assembly Regulation Of Dendritic Spine Development Regulation Of Protein Localization To Plasma Membrane
Tagcloud ?		adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 vamp4 verify vps4b wizened	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk3 stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Difference) ?		adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 vamp4 verify vps4b wizened	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk3 stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Intersection) ?