PARD6B and RHOQ

Number of citations of the paper that reports this interaction (PMID 10934474)
205

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid)

		PARD6B	RHOQ
Gene Name		par-6 family cell polarity regulator beta	ras homolog family member Q
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Tight Junction Cell Cortex Protein Complex Apical Part Of Cell Extracellular Vesicular Exosome	Cytosol Actin Filament Plasma Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	GTPase Activity Profilin Binding GTP Binding GBD Domain Binding
	Biological Process	Protein Complex Assembly Cell-cell Junction Assembly Cell Cycle Establishment Or Maintenance Of Cell Polarity Axonogenesis Regulation Of Cell Migration Cell Junction Assembly Cell-cell Junction Organization Cell Division Tight Junction Assembly	Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Filopodium Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		Cell junction organization Cell-cell junction organization Tight junction interactions	Rho GTPase cycle Signaling by Rho GTPases Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Bipolar disorder ( 21771265)
Protein-Protein Interactions		22 interactors: APP CDC42 CEP76 GMCL1 GOLGA2 HTRA1 MPP5 PARD3 PARD3B PARD6A PNMA1 PRKCG PRKCI PRKCZ RAC1 RHOJ RHOQ TCP10 WDR83 YWHAB YWHAH YWHAZ	18 interactors: CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DOCK8 EXOC7 GOPC PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL
Entrez ID		84612	23433
HPRD ID		18703	05791
Ensembl ID		ENSG00000124171
Uniprot IDs		Q9BYG5	P17081
PDB IDs			2ATX
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Enzyme Linked Receptor Protein Signaling Pathway Tight Junction Assembly Regulation Of Cellular Component Organization Membrane Organization Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apical Junction Assembly Wound Healing Response To Growth Factor Platelet Activation Positive Regulation Of Cell Death Actin Filament-based Process Cellular Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Intracellular Signal Transduction Blood Coagulation Regulation Of Cellular Localization Hemostasis Response To Wounding Cellular Component Assembly Regulation Of Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Protein Localization Cell-cell Junction Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Glucose Import Neurogenesis Positive Regulation Of Glucose Transport Regulation Of Body Fluid Levels Nervous System Development Regulation Of Organelle Organization Actin Cytoskeleton Organization Defense Response Establishment Of Golgi Localization Neuron Development Protein Localization To Membrane Cellular Localization Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Establishment Or Maintenance Of Cell Polarity Protein Localization Regulation Of Glucose Import Positive Regulation Of Mitochondrion Organization	Positive Regulation Of Cell Projection Organization Positive Regulation Of Pseudopodium Assembly Regulation Of Cell Projection Assembly Regulation Of Cell Projection Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Positive Regulation Of Cellular Component Biogenesis Golgi Vesicle Budding Positive Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Membrane Budding Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Regulation Of Catalytic Activity Intracellular Signal Transduction Regulation Of Cellular Component Size Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Small GTPase Mediated Signal Transduction Localization Within Membrane Vesicle-mediated Transport Actin Filament-based Process Positive Regulation Of Hydrolase Activity Regulation Of Cell Shape Tight Junction Assembly Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Ras GTPase Activity Cell Junction Assembly Regulation Of GTPase Activity Vesicle Organization Cell-cell Junction Organization Ras Protein Signal Transduction Apical Junction Assembly Organelle Organization Positive Regulation Of Rho GTPase Activity COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of Organelle Organization Regulation Of Ras GTPase Activity Golgi Vesicle Transport Regulation Of Rho GTPase Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 vamp4 verify vps4b wizened
Tagcloud (Difference) ?		adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 vamp4 verify vps4b wizened
Tagcloud (Intersection) ?