PARD6B and RHOQ

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid, in vitro)

		PARD6B	RHOQ
Description		par-6 family cell polarity regulator beta	ras homolog family member Q
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Apical Part Of Cell Extracellular Exosome Tight Junction Anchoring Junction PAR Polarity Complex	Cytoplasm Actin Filament Plasma Membrane Membrane Golgi-associated Vesicle Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding GTPase Activity Protein Binding Profilin Binding GTP Binding Protein Kinase Binding GBD Domain Binding
	Biological Process	Cell-cell Junction Assembly Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Axonogenesis Regulation Of Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Regulation Of Cellular Localization Protein-containing Complex Assembly	Endocytosis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Establishment Of Cell Polarity Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription By RNA Polymerase II GTP Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of Filopodium Assembly Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Tight junction interactions RHOV GTPase cycle	Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 21771265)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		34 interacting genes: APP ARAP3 BANP CDC42 CDCA4 CEP76 FRMD6 GMCL1 GOLGA2 HSF2BP HTRA1 MAGOHB OGT PALS1 PARD3 PARD3B PARD6A PNMA1 PRKCG PRKCI PRKCZ RAC1 RASSF3 RHOJ RHOQ SIAH1 TCP10L3 TRIB3 TRIM35 WDR83 YWHAB YWHAH YWHAZ ZSCAN4	22 interacting genes: BANP CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DOCK8 EXOC7 GOPC MORN4 NTAQ1 PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL ZNF417
Entrez ID		84612	23433
HPRD ID		18703	05791
Ensembl ID		ENSG00000124171	ENSG00000119729
Uniprot IDs		Q9BYG5	P17081 V9HWD0
PDB IDs			2ATX
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity PAR Polarity Complex Establishment Of Cell Polarity Bicellular Tight Junction Apical Junction Complex Tight Junction GBD Domain Binding Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity GTP-dependent Protein Binding Cytoskeleton Organization Intracellular Protein Localization Response To Insulin Cell-cell Junction Organization Protein Kinase Binding Cell Cortex Response To Peptide Hormone Supramolecular Fiber Organization Cellular Response To Insulin Stimulus Regulation Of Synaptic Plasticity Phosphoserine Residue Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Apical Plasma Membrane G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Identical Protein Binding Intracellular Signal Transduction Establishment Of Golgi Localization Negative Regulation Of Protein Localization To Nucleus Actin Filament Organization Thioesterase Binding Establishment Of Centrosome Localization Organelle Organization Schmidt-Lanterman Incisure Plasma Membrane Cell Junction Organization Asymmetric Cell Division Regulation Of Synapse Organization Regulation Of Protein Localization Golgi Localization Regulation Of Cell Communication Extracellular Exosome Regulation Of Signaling Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Cellular Response To Peptide Hormone Stimulus Regulation Of Insulin Receptor Signaling Pathway Regulation Of D-glucose Transmembrane Transport Cellular Localization	Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Cytoplasm PAR Polarity Complex Positive Regulation Of Protein Polymerization Cytosol Regulation Of Cell Projection Assembly Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Small GTPase-mediated Signal Transduction Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Organization Small GTPase Binding Rho Protein Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Cytoskeleton Tight Junction Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Regulation Of Cell Shape Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Cell Leading Edge Regulation Of Actin Cytoskeleton Organization Cell Cortex Actin Cytoskeleton Organization Plasma Membrane COPI Vesicle Coat Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Filament-based Process COPI-coated Vesicle Membrane Regulation Of Protein-containing Complex Assembly Regulation Of Cell Morphogenesis Cell Junction Organization Endomembrane System Positive Regulation Of Organelle Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cytoskeleton Organization Bicellular Tight Junction Membrane Coat Intracellular Signaling Cassette Centriolar Satellite
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