TUBB and PFDN4

Number of citations of the paper that reports this interaction (PMID 14634002)
12

Data Source:
HPRD (in vitro)

		TUBB	PFDN4
Gene Name		tubulin, beta class I	prefoldin subunit 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Cytosol Cytoskeleton Microtubule Cytoplasmic Ribonucleoprotein Granule Cell Body Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Complex Binding GTPase Activating Protein Binding MHC Class I Protein Binding	Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Organelle Organization Microtubule-based Process Cellular Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Spindle Assembly Protein Polymerization Cell Division	Protein Folding Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic	Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Epothilone B
Diseases
GWAS			Atopic dermatitis ( 23042114) Obesity-related traits ( 23251661)
Protein-Protein Interactions		61 interactors: ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CCT2 CDKN2A CLIP1 CMTM5 CNN1 CRIPT DISC1 DPYSL2 DYNLL1 ESR1 GDAP1 GNB2L1 GRM1 HDAC6 HGS HTRA2 HTT MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MX1 NCALD NCAM1 NPHP1 PARK2 PFDN4 PLK1 RAB8B RASSF1 SDC3 SIRT2 SPP1 STAU1 SYT9 TAOK2 TBCD TGM2 TINF2 TTBK1 TTK TUBA1A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	5 interactors: ACTB PFDN2 TUBA4A TUBB VBP1
Entrez ID		203068	5203
HPRD ID		01852	05358
Ensembl ID		ENSG00000196230	ENSG00000101132
Uniprot IDs		B4DMJ5 P07437 Q5ST81 Q5SU16	Q9NQP4
PDB IDs		3QNZ 3QO0
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cytoskeleton Organization Microtubule Cytoskeleton Organization Positive Regulation Of Signal Transduction Cellular Localization Microtubule-based Process Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Cell Death Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Process Cell Communication Cellular Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Signaling Regulation Of Apoptotic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Cycle Signal Transduction Cell Cycle Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Negative Regulation Of Protein Metabolic Process Mitotic Cell Cycle Nervous System Development Regulation Of Protein Localization	'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Protein Folding Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Platelet Activation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Complex Assembly Blood Coagulation Hemostasis Microtubule Cytoskeleton Organization Cellular Component Assembly Cellular Protein Metabolic Process Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of Body Fluid Levels Wound Healing Cellular Macromolecular Complex Assembly Leukocyte Mediated Cytotoxicity Mitotic Cell Cycle Process Cell Activation Substantia Nigra Development Response To Wounding Platelet Aggregation Cellular Response To Interleukin-4 Mitotic Cell Cycle Microtubule-based Process Response To Interleukin-4 Innate Immune Response Neural Nucleus Development Protein Metabolic Process Retina Homeostasis
Tagcloud ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	12p11 13q11 16q24 1p32 20q13 3q21 bacs cdkn1b cgh chromosomes copy cyp24 fstl1 heterozygosity hyperplastic informative loh16 loh9 narrowed overcomes p13 ppp2r3 q25 q32 rip stmn1 sv40 syntenic unappreciated
Tagcloud (Difference) ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	12p11 13q11 16q24 1p32 20q13 3q21 bacs cdkn1b cgh chromosomes copy cyp24 fstl1 heterozygosity hyperplastic informative loh16 loh9 narrowed overcomes p13 ppp2r3 q25 q32 rip stmn1 sv40 syntenic unappreciated
Tagcloud (Intersection) ?