TUBB and MAP6

Number of citations of the paper that reports this interaction (PubMedID 8700896)
43

Data Source:
HPRD (in vitro, in vivo)

		TUBB	MAP6
Description		tubulin beta class I	microtubule associated protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Intercellular Bridge Extracellular Exosome Mitotic Spindle	Cytoplasm Golgi Apparatus Golgi-associated Vesicle Cis-Golgi Network Cytoskeleton Microtubule Membrane Axon Dendrite Transport Vesicle Membrane Cytoplasmic Vesicle Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding Metal Ion Binding	Protein Binding Calmodulin Binding Microtubule Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Regulation Of Synapse Organization Spindle Assembly Cell Division Odontoblast Differentiation	Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Lysosome Localization Dendrite Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Microtubule Cytoskeleton Organization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		84 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BCL2L13 BMPR2 BRCA1 CDK1 CDKN2A CLIP1 CMTM5 CNN1 CREBBP CRIPT DISC1 DPYSL2 DUX4 DYNLL1 EML4 ESR1 FXR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 OGT PFDN4 PLK1 PRKN PRMT1 PTEN RAB8B RACK1 RASSF1 RSPH1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TBKBP1 TGM2 TINF2 TPPP TTBK1 TTK TUBA1A UBE3A USP25 VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19	7 interacting genes: GRSF1 NR2F1 RARB RARG RORB TRAF1 TUBB
Entrez ID		203068	4135
HPRD ID		01852	15989
Ensembl ID		ENSG00000196230	ENSG00000171533
Uniprot IDs		B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16	Q96JE9
PDB IDs		3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ 7TRG 7TTN 7TTT 7TUB 7X0S 8BPO 8T42 8U3Z 8V2J 9BP6
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Microtubule Cytoskeleton Organization Organelle Organization Microtubule Binding Microtubule Regulation Of Cellular Component Organization Cytoskeleton Organization Microtubule Polymerization Tubulin Binding Identical Protein Binding Microtubule Cytoskeleton Microtubule Associated Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Polymerization Or Depolymerization Cytoskeleton Cytosol Neuron Projection Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Regulation Of Organelle Organization Cytoplasm Cytoskeleton-dependent Intracellular Transport Protein Polymerization Positive Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Axon Protein Localization To Organelle Transport Along Microtubule Regulation Of Protein Localization Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Growth Regulation Of Cellular Response To Stress Apoptotic Process Dendrite Alpha-tubulin Binding Regulation Of Microtubule-based Process Tau Protein Binding Synapse Programmed Cell Death Cell Death Microtubule-based Transport Regulation Of Microtubule Cytoskeleton Organization Axo-dendritic Transport Regulation Of Intracellular Signal Transduction Cilium Disassembly	Nuclear Receptor Activity Glandular Epithelial Cell Development Intracellular Receptor Signaling Pathway Growth Plate Cartilage Development Nuclear Retinoid X Receptor Binding Sequence-specific DNA Binding Columnar/cuboidal Epithelial Cell Development Cartilage Development Involved In Endochondral Bone Morphogenesis Negative Regulation Of Chondrocyte Differentiation Sequence-specific Double-stranded DNA Binding Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Stem Cell Proliferation Embryonic Hindlimb Morphogenesis Embryonic Eye Morphogenesis Negative Regulation Of Cartilage Development DNA-binding Transcription Factor Activity Hindlimb Morphogenesis Regulation Of Myelination Regulation Of Chondrocyte Differentiation Positive Regulation Of RNA Metabolic Process Eye Morphogenesis Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Sensory Organ Morphogenesis Regulation Of Cartilage Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Connective Tissue Development Bone Development Cellular Response To Retinoic Acid Stem Cell Proliferation Embryonic Morphogenesis Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Limb Morphogenesis Cartilage Development Multicellular Organism Growth Nuclear Receptor-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Retinoic Acid Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Organ Morphogenesis Positive Regulation Of Mitochondrial RNA Catabolic Process Epithelial Cell Development RNA Polymerase II Transcription Regulator Complex Growth Plate Cartilage Chondrocyte Growth Negative Regulation Of RNA Metabolic Process
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