TUBB and MAP4

Number of citations of the paper that reports this interaction (PMID 12855424)
10

Data Source:
HPRD (in vitro)

		TUBB	MAP4
Gene Name		tubulin, beta class I	microtubule-associated protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Cytosol Cytoskeleton Microtubule Cytoplasmic Ribonucleoprotein Granule Cell Body Extracellular Vesicular Exosome	Cytoplasm Microtubule Microtubule Associated Complex Plasma Membrane Microtubule Cytoskeleton Extracellular Vesicular Exosome Mitotic Spindle
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Complex Binding GTPase Activating Protein Binding MHC Class I Protein Binding	Structural Molecule Activity Protein Binding Microtubule Binding Poly(A) RNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Organelle Organization Microtubule-based Process Cellular Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Spindle Assembly Protein Polymerization Cell Division	Mitotic Spindle Organization Microtubule Sliding Establishment Of Spindle Orientation Cell Division
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Epothilone B
Diseases
GWAS			Blood pressure ( 21909110)
Protein-Protein Interactions		61 interactors: ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CCT2 CDKN2A CLIP1 CMTM5 CNN1 CRIPT DISC1 DPYSL2 DYNLL1 ESR1 GDAP1 GNB2L1 GRM1 HDAC6 HGS HTRA2 HTT MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MX1 NCALD NCAM1 NPHP1 PARK2 PFDN4 PLK1 RAB8B RASSF1 SDC3 SIRT2 SPP1 STAU1 SYT9 TAOK2 TBCD TGM2 TINF2 TTBK1 TTK TUBA1A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	16 interactors: CCNB1 CDK1 ENO2 ERBB2IP GSK3B IL7R LDLR MARK1 MARK4 NR1I3 POT1 RXRB RXRG SNTA1 TERF1 TUBB
Entrez ID		203068	4134
HPRD ID		01852	01141
Ensembl ID		ENSG00000196230	ENSG00000047849
Uniprot IDs		B4DMJ5 P07437 Q5ST81 Q5SU16	E7EVA0 P27816
PDB IDs		3QNZ 3QO0
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cytoskeleton Organization Microtubule Cytoskeleton Organization Positive Regulation Of Signal Transduction Cellular Localization Microtubule-based Process Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Cell Death Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Process Cell Communication Cellular Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Signaling Regulation Of Apoptotic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Cycle Signal Transduction Cell Cycle Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Negative Regulation Of Protein Metabolic Process Mitotic Cell Cycle Nervous System Development Regulation Of Protein Localization	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Ventricular Cardiac Muscle Cell Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Cell Cycle Striated Muscle Cell Differentiation Muscle Structure Development Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Gene Expression Cell Cycle Process Positive Regulation Of Cellular Biosynthetic Process Steroid Hormone Mediated Signaling Pathway Regulation Of Telomerase Activity Regulation Of Nitrogen Compound Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Muscle Tissue Development Mitotic Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Ventricular Cardiac Muscle Cell Development Regulation Of Telomere Maintenance Regulation Of DNA Replication Cardiocyte Differentiation Hormone-mediated Signaling Pathway RNA-dependent DNA Replication Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of DNA Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Lipid Positive Regulation Of Developmental Growth Cell Division G1/S Transition Of Mitotic Cell Cycle Retinoic Acid Receptor Signaling Pathway Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	brefeldin constructs dextran dic distributions golgi impacts inducibly mock morphogenesis motility movements mt mts organellar organelle overexpress overexpressed polarization repositioning retarded stabilization stabilize stabilized steady taxol transferrin unusual vesicle
Tagcloud (Difference) ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	brefeldin constructs dextran dic distributions golgi impacts inducibly mock morphogenesis motility movements mt mts organellar organelle overexpress overexpressed polarization repositioning retarded stabilization stabilize stabilized steady taxol transferrin unusual vesicle
Tagcloud (Intersection) ?