TUBB and B4GALT1

Number of citations of the paper that reports this interaction (PMID 7744867)
23

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		TUBB	B4GALT1
Gene Name		tubulin, beta class I	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Cytosol Cytoskeleton Microtubule Cytoplasmic Ribonucleoprotein Granule Cell Body Extracellular Vesicular Exosome	Golgi Trans Cisterna Golgi Membrane Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Desmosome Glycocalyx Filopodium Brush Border Membrane Golgi Cisterna Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Complex Binding GTPase Activating Protein Binding MHC Class I Protein Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Cytoskeletal Protein Binding Galactosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity Protein Homodimerization Activity Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Organelle Organization Microtubule-based Process Cellular Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Spindle Assembly Protein Polymerization Cell Division	Epithelial Cell Development Acute Inflammatory Response Carbohydrate Metabolic Process Lactose Biosynthetic Process Galactose Metabolic Process Protein N-linked Glycosylation Cell Adhesion Notch Signaling Pathway Single Fertilization Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Negative Regulation Of Cell Proliferation Oligosaccharide Biosynthetic Process Pathogenesis Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Mammary Gland Development Multicellular Organism Reproduction Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Development Of Secondary Sexual Characteristics Branching Morphogenesis Of An Epithelial Tube Leukocyte Migration Regulation Of Cellular Component Movement Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic	Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) Fertilization N-Glycan antennae elongation Defective CHST14 causes EDS, musculocontractural type N-glycan antennae elongation in the medial/trans-Golgi Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Keratan sulfate biosynthesis Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Signaling by NOTCH Defective EXT2 causes exostoses 2 Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Pre-NOTCH Expression and Processing Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Pre-NOTCH Processing in Golgi Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Interaction With The Zona Pellucida
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Epothilone B	N-Acetyl-D-glucosamine 6-Aminohexyl-Uridine-C1,5\'-Diphosphate Di(N-Acetyl-D-Glucosamine) Uridine Diphosphate Galactose Uridine-5\'-Monophosphate 2-(N-Morpholino)-Ethanesulfonic Acid
Diseases
GWAS			IgG glycosylation ( 23382691) Urate levels ( 23263486)
Protein-Protein Interactions		61 interactors: ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CCT2 CDKN2A CLIP1 CMTM5 CNN1 CRIPT DISC1 DPYSL2 DYNLL1 ESR1 GDAP1 GNB2L1 GRM1 HDAC6 HGS HTRA2 HTT MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MX1 NCALD NCAM1 NPHP1 PARK2 PFDN4 PLK1 RAB8B RASSF1 SDC3 SIRT2 SPP1 STAU1 SYT9 TAOK2 TBCD TGM2 TINF2 TTBK1 TTK TUBA1A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	6 interactors: CDK11A LALBA TFRC TUBA1A TUBA4A TUBB
Entrez ID		203068	2683
HPRD ID		01852	00659
Ensembl ID		ENSG00000196230	ENSG00000086062
Uniprot IDs		B4DMJ5 P07437 Q5ST81 Q5SU16	P15291
PDB IDs		3QNZ 3QO0	2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cytoskeleton Organization Microtubule Cytoskeleton Organization Positive Regulation Of Signal Transduction Cellular Localization Microtubule-based Process Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Cell Death Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Process Cell Communication Cellular Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Signaling Regulation Of Apoptotic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Cycle Signal Transduction Cell Cycle Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Negative Regulation Of Protein Metabolic Process Mitotic Cell Cycle Nervous System Development Regulation Of Protein Localization	Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Interleukin-4 Cell Cycle Process Cellular Protein Complex Assembly Response To Interleukin-4 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Microtubule Cytoskeleton Organization Cell Cycle Cellular Macromolecular Complex Assembly Lactose Biosynthetic Process Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Disaccharide Metabolic Process Protein Complex Assembly Cytoskeleton Organization Protein Folding Iron Ion Import Organelle Organization Positive Regulation Of Bone Resorption Oligosaccharide Biosynthetic Process Cell Division Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Positive Regulation Of Tissue Remodeling Transferrin Transport Leukocyte Mediated Cytotoxicity Cellular Component Assembly Cellular Response To Cytokine Stimulus Regulation Of Bone Resorption Establishment Of Localization In Cell Regulation Of Bone Remodeling Osteoclast Differentiation Response To Cytokine Oligosaccharide Metabolic Process Cellular Response To Drug Cellular Localization Regulation Of Tissue Remodeling
Tagcloud ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	acetylglucosaminyltransferase amidase antennae asparagine atp6v0a2 cdg cdgs cog7 documents fucose fucosylation galactosyltransferase glucosaminyl glycan glycans isofocusing mannosyl mgat2 n4 permethylated pngase sialidase slc35c1 transporting triantennary underglycosylation undersialylation unsolved v0
Tagcloud (Difference) ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	acetylglucosaminyltransferase amidase antennae asparagine atp6v0a2 cdg cdgs cog7 documents fucose fucosylation galactosyltransferase glucosaminyl glycan glycans isofocusing mannosyl mgat2 n4 permethylated pngase sialidase slc35c1 transporting triantennary underglycosylation undersialylation unsolved v0
Tagcloud (Intersection) ?