TUBB and SDC3

Number of citations of the paper that reports this interaction (PMID 9553134)
37

Data Source:
HPRD (in vitro)

		TUBB	SDC3
Gene Name		tubulin, beta class I	syndecan 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Cytosol Cytoskeleton Microtubule Cytoplasmic Ribonucleoprotein Granule Cell Body Extracellular Vesicular Exosome	Golgi Lumen Plasma Membrane Membrane Integral Component Of Membrane Lysosomal Lumen
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Complex Binding GTPase Activating Protein Binding MHC Class I Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Organelle Organization Microtubule-based Process Cellular Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Spindle Assembly Protein Polymerization Cell Division	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Epothilone B
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CCT2 CDKN2A CLIP1 CMTM5 CNN1 CRIPT DISC1 DPYSL2 DYNLL1 ESR1 GDAP1 GNB2L1 GRM1 HDAC6 HGS HTRA2 HTT MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MX1 NCALD NCAM1 NPHP1 PARK2 PFDN4 PLK1 RAB8B RASSF1 SDC3 SIRT2 SPP1 STAU1 SYT9 TAOK2 TBCD TGM2 TINF2 TTBK1 TTK TUBA1A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	15 interactors: CASK COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN KRTAP10-3 KRTAP5-9 MDK PTN TUBA1A TUBB TUBB2A
Entrez ID		203068	9672
HPRD ID		01852	01719
Ensembl ID		ENSG00000196230
Uniprot IDs		B4DMJ5 P07437 Q5ST81 Q5SU16	O75056
PDB IDs		3QNZ 3QO0
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cytoskeleton Organization Microtubule Cytoskeleton Organization Positive Regulation Of Signal Transduction Cellular Localization Microtubule-based Process Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Cell Death Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Process Cell Communication Cellular Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Signaling Regulation Of Apoptotic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Cycle Signal Transduction Cell Cycle Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Negative Regulation Of Protein Metabolic Process Mitotic Cell Cycle Nervous System Development Regulation Of Protein Localization	Cell Migration Cell Motility Protein Polymerization Movement Of Cell Or Subcellular Component Nervous System Development Locomotion Anatomical Structure Development Organ Development System Development Developmental Process Response To Wounding Cellular Protein Complex Assembly Multicellular Organismal Development Positive Regulation Of Cell Division Cell Migration Involved In Sprouting Angiogenesis Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Vessel Endothelial Cell Migration Neurogenesis Protein Autophosphorylation Cell Differentiation Peptidyl-tyrosine Autophosphorylation Tissue Development Epithelium Development Neuron Differentiation Wound Healing Chemotaxis Cellular Macromolecular Complex Assembly Neuron Projection Morphogenesis Cell Adhesion Regulation Of Cell Division Learning Or Memory Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Sprouting Angiogenesis 'de Novo' Posttranslational Protein Folding Cognition 'de Novo' Protein Folding Defecation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Integrin Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Defense Response Negative Regulation Of Wound Healing Cellular Response To Peptide T Cell Costimulation Innate Immune Response Neuron Projection Development Endothelial Cell Migration
Tagcloud ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	artemin artn benign carcinoma diverse gfralpha1 gfralpha3 herein invasiveness largely malignancies mammary mediating metastases namely node oncogenicity outcome positively positivity predictors promoting relapse restricted significance syndecan synergistic univariate upstream
Tagcloud (Difference) ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	artemin artn benign carcinoma diverse gfralpha1 gfralpha3 herein invasiveness largely malignancies mammary mediating metastases namely node oncogenicity outcome positively positivity predictors promoting relapse restricted significance syndecan synergistic univariate upstream
Tagcloud (Intersection) ?