TUBB and RAB8B

Number of citations of the paper that reports this interaction (PubMedID 12639940)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TUBB	RAB8B
Description		tubulin beta class I	RAB8B, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Intercellular Bridge Extracellular Exosome Mitotic Spindle	Endosome Peroxisomal Membrane Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle Phagocytic Vesicle Membrane Cytoplasmic Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Cell Tip Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Presynapse
	Molecular Function	Nucleotide Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding Metal Ion Binding	Nucleotide Binding GTPase Activity Signaling Receptor Binding Protein Binding GTP Binding Hydrolase Activity GDP Binding TPR Domain Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Regulation Of Synapse Organization Spindle Assembly Cell Division Odontoblast Differentiation	Exocytosis Protein Transport Antigen Processing And Presentation Positive Regulation Of Cell Projection Organization Endocytic Recycling Protein Import Into Peroxisome Membrane Positive Regulation Of Corticotropin Secretion Cilium Assembly Cell-substrate Junction Organization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS	TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine	Phosphoaminophosphonic acid guanylate ester Guanosine-5'-Diphosphate
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Refractive error ( 32231278) Serum metabolite levels ( 23093944) Social communication problems ( 24564958)
Interacting Genes		84 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BCL2L13 BMPR2 BRCA1 CDK1 CDKN2A CLIP1 CMTM5 CNN1 CREBBP CRIPT DISC1 DPYSL2 DUX4 DYNLL1 EML4 ESR1 FXR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 OGT PFDN4 PLK1 PRKN PRMT1 PTEN RAB8B RACK1 RASSF1 RSPH1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TBKBP1 TGM2 TINF2 TPPP TTBK1 TTK TUBA1A UBE3A USP25 VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19	7 interacting genes: APP CDH1 RAB3IP RALA TUBA4A TUBB VIM
Entrez ID		203068	51762
HPRD ID		01852	11476
Ensembl ID		ENSG00000196230	ENSG00000166128
Uniprot IDs		B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16	Q92930
PDB IDs		3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ 7TRG 7TTN 7TTT 7TUB 7X0S 8BPO 8T42 8U3Z 8V2J 9BP6
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Microtubule Cytoskeleton Organization Organelle Organization Microtubule Binding Microtubule Regulation Of Cellular Component Organization Cytoskeleton Organization Microtubule Polymerization Tubulin Binding Identical Protein Binding Microtubule Cytoskeleton Microtubule Associated Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Polymerization Or Depolymerization Cytoskeleton Cytosol Neuron Projection Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Regulation Of Organelle Organization Cytoplasm Cytoskeleton-dependent Intracellular Transport Protein Polymerization Positive Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Axon Protein Localization To Organelle Transport Along Microtubule Regulation Of Protein Localization Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Growth Regulation Of Cellular Response To Stress Apoptotic Process Dendrite Alpha-tubulin Binding Regulation Of Microtubule-based Process Tau Protein Binding Synapse Programmed Cell Death Cell Death Microtubule-based Transport Regulation Of Microtubule Cytoskeleton Organization Axo-dendritic Transport Regulation Of Intracellular Signal Transduction Cilium Disassembly	Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Extracellular Exosome Cellular Localization Nuclear Envelope Lumen GTPase Activating Protein Binding Structural Constituent Of Cytoskeleton Negative Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Plasma Membrane Bounded Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glial Cell Development GTP Binding Regulation Of Receptor Internalization Cell Body Acetylcholine Receptor Activator Activity Lipoprotein Particle Cell Projection Organization Positive Regulation Of Protein Import Edg-2 Lysophosphatidic Acid Receptor Binding Dense Core Granule Membrane Negative Regulation Of Type 2 Mitophagy Ciliary Basal Body-plasma Membrane Docking PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Vesicle-mediated Transport Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Neuron Projection Development Post-Golgi Vesicle-mediated Transport Localization Within Membrane Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Response To External Biotic Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling
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