PLA2G10 and PLA2R1

Number of citations of the paper that reports this interaction (PMID 11019817)
11

Data Source:
HPRD (in vivo, in vitro)

		PLA2G10	PLA2R1
Gene Name		phospholipase A2, group X	phospholipase A2 receptor 1, 180kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding	Receptor Activity Carbohydrate Binding Phospholipase Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Axon Guidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonic Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Macrophage Activation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Lysophospholipid Transport Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Efflux	Cytokine Production Endocytosis Receptor-mediated Endocytosis Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Arachidonic Acid Secretion Replicative Senescence Oxidative Stress-induced Premature Senescence Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Arachidonic Acid Secretion
Pathways		Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs
Diseases
GWAS			Bilirubin levels ( 20639394) Nephropathy (idiopathic membranous) ( 21323541)
Protein-Protein Interactions		2 interactors: MYO10 PLA2R1	2 interactors: PLA2G10 PLA2G2A
Entrez ID		8399	22925
HPRD ID		04674	09222
Ensembl ID		ENSG00000069764	ENSG00000153246
Uniprot IDs		O15496	B7ZML4 Q13018
PDB IDs		1LE6 1LE7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Arachidonic Acid Secretion Negative Regulation Of Icosanoid Secretion Negative Regulation Of Phospholipase A2 Activity Positive Regulation Of Arachidonic Acid Secretion Regulation Of Arachidonic Acid Secretion Negative Regulation Of Phospholipase Activity Oxidative Stress-induced Premature Senescence Endocytosis Stress-induced Premature Senescence Regulation Of Phospholipase A2 Activity Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Positive Regulation Of Icosanoid Secretion Negative Regulation Of Lipase Activity Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Transport Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Senescence Regulation Of Fatty Acid Transport Regulation Of Signal Transduction By P53 Class Mediator Vesicle-mediated Transport Regulation Of Filopodium Assembly Positive Regulation Of Lipid Transport Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Regulation Of Phospholipase Activity Regulation Of Lipid Transport Negative Regulation Of Ion Transport Reactive Oxygen Species Metabolic Process Regulation Of Cell Projection Assembly Regulation Of Response To DNA Damage Stimulus Cytokine Production Cytoskeleton-dependent Intracellular Transport Regulation Of Anion Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cell Shape Negative Regulation Of Secretion Cellular Response To Oxidative Stress Positive Regulation Of Ion Transport	Phosphatidylinositol Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Phosphatidylserine Metabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Macrophage Derived Foam Cell Differentiation Phosphatidylcholine Metabolic Process Cellular Biogenic Amine Metabolic Process Amine Metabolic Process Glycerophospholipid Biosynthetic Process Lysophospholipid Transport Phosphatidylinositol Metabolic Process Phospholipid Biosynthetic Process Lipid Catabolic Process Cellular Modified Amino Acid Metabolic Process Glycerophospholipid Metabolic Process Alcohol Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Negative Regulation Of Cholesterol Efflux Positive Regulation Of Arachidonic Acid Secretion Lipid Biosynthetic Process Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Transport Low-density Lipoprotein Particle Remodeling Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Cell Differentiation Positive Regulation Of Icosanoid Secretion Cellular Lipid Metabolic Process Organophosphate Metabolic Process Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Transport Regulation Of Macrophage Activation Plasma Lipoprotein Particle Remodeling Regulation Of Fatty Acid Transport Positive Regulation Of Lipid Storage Lipid Metabolic Process Regulation Of Cholesterol Transport Carbohydrate Derivative Transport Regulation Of Cell Differentiation Regulation Of Lipid Storage Positive Regulation Of Lipid Transport Regulation Of Plasma Lipoprotein Particle Levels Arachidonic Acid Metabolic Process Defense Response To Gram-positive Bacterium
Tagcloud ?		adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 polr2k rpl14 rpl41 rpl8 rps17 rps24 rps5 snrpa srp9 ssh subtractive underexpressed zbtb11 zip14	2000s alloimmune ancestry basel cationic come definition deposited dqa1 endopeptidase exaggerated faithful heymann idiopathic inspired karger membranous mn nephritis nephropathy opening pathomechanisms personalized phospholipase revisit signatures uncertainties uniform
Tagcloud (Difference) ?		adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 polr2k rpl14 rpl41 rpl8 rps17 rps24 rps5 snrpa srp9 ssh subtractive underexpressed zbtb11 zip14	2000s alloimmune ancestry basel cationic come definition deposited dqa1 endopeptidase exaggerated faithful heymann idiopathic inspired karger membranous mn nephritis nephropathy opening pathomechanisms personalized phospholipase revisit signatures uncertainties uniform
Tagcloud (Intersection) ?