PLA2G10 and PLA2R1

Number of citations of the paper that reports this interaction (PubMedID 11019817)
0

Data Source:
HPRD (in vivo, in vitro)

		PLA2G10	PLA2R1
Description		phospholipase A2 group X	phospholipase A2 receptor 1
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle	Extracellular Region Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity	Phospholipase A2 Inhibitor Activity Carbohydrate Binding Signaling Receptor Activity Phospholipase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Prostaglandin Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Axon Guidance Fertilization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonate Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Hair Follicle Morphogenesis Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Intestinal Stem Cell Homeostasis Macrophage Activation Cholesterol Homeostasis Regulation Of Macrophage Activation Erythrocyte Maturation Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonate Secretion Negative Regulation Of Cholesterol Efflux Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Acrosome Reaction	Positive Regulation Of Cytokine Production Endocytosis Receptor-mediated Endocytosis Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Arachidonate Secretion Replicative Senescence Oxidative Stress-induced Premature Senescence Negative Regulation Of Arachidonate Secretion Positive Regulation Of Podocyte Apoptotic Process
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs		Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases
GWAS		Cholesteryl ester levels ( 31551469)	Bilirubin levels ( 20639394) Blood protein levels ( 30072576) Crohn's disease ( 26192919) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 26192919) Membranous nephropathy ( 27333618 32231244) Platelet count ( 32888494) Plateletcrit ( 32888494) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278) Tourette syndrome ( 30818990) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		55 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXA1 HOXC8 HR HSF4 INCA1 KPRP KRTAP10-8 KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE1F LCE2A LCE2B LCE2D LCE3A LCE5A MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 PLSCR4 POU4F3 ROR2 SAXO4 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10	2 interacting genes: PLA2G10 PLA2G2A
Entrez ID		8399	22925
HPRD ID		04674	09222
Ensembl ID		ENSG00000069764	ENSG00000153246
Uniprot IDs		O15496	B7ZML4 Q13018
PDB IDs		1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J	6JLI 7QSR
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Tissue Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Protein Binding Chromatin	Intestinal Stem Cell Homeostasis Positive Regulation Of Macrophage Derived Foam Cell Differentiation Low-density Lipoprotein Particle Remodeling Calcium-dependent Phospholipase A2 Activity Arachidonate Secretion Phospholipase A2 Activity Phosphatidylglycerol Metabolic Process Phosphatidylethanolamine Metabolic Process Phosphatidic Acid Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Long-chain Fatty Acid Transport Phosphatidylcholine Metabolic Process Fatty Acid Transport Phospholipid Binding Monocarboxylic Acid Transport Homeostasis Of Number Of Cells Platelet Activating Factor Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Lysophospholipid Transport Carboxylic Acid Transport Organic Acid Transport Glycerophospholipid Metabolic Process Lipid Catabolic Process Positive Regulation Of Arachidonate Secretion Lipid Transport Glycerolipid Metabolic Process Regulation Of Arachidonate Secretion Phospholipid Metabolic Process Organic Anion Transport 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Platelet Activating Factor Metabolic Process Positive Regulation Of Acrosome Reaction Regulation Of Inflammatory Response Regulation Of Neutrophil Activation Voltage-gated Sodium Channel Complex Phosphatidylcholine Catabolic Process Positive Regulation Of Prostaglandin Secretion Production Of Molecular Mediator Involved In Inflammatory Response Multicellular Organismal-level Homeostasis Regulation Of Acrosome Reaction Negative Regulation Of Cholesterol Efflux Secretion Prostaglandin Biosynthetic Process Voltage-gated Sodium Channel Activity Positive Regulation Of Icosanoid Secretion Angiotensin-activated Signaling Pathway Calcium Ion Binding Node Of Ranvier
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