PLA2G10

Gene Name		phospholipase A2, group X
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region
	Molecular Function	Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Axon Guidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonic Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Macrophage Activation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Lysophospholipid Transport Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Efflux
Pathways		Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: MYO10 PLA2R1
Entrez ID		8399
HPRD ID		04674
Ensembl ID		ENSG00000069764
Uniprot IDs		O15496
PDB IDs		1LE6 1LE7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Arachidonic Acid Secretion Negative Regulation Of Icosanoid Secretion Negative Regulation Of Phospholipase A2 Activity Positive Regulation Of Arachidonic Acid Secretion Regulation Of Arachidonic Acid Secretion Negative Regulation Of Phospholipase Activity Oxidative Stress-induced Premature Senescence Endocytosis Stress-induced Premature Senescence Regulation Of Phospholipase A2 Activity Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Positive Regulation Of Icosanoid Secretion Negative Regulation Of Lipase Activity Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Transport Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Senescence Regulation Of Fatty Acid Transport Regulation Of Signal Transduction By P53 Class Mediator Vesicle-mediated Transport Regulation Of Filopodium Assembly Positive Regulation Of Lipid Transport Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Regulation Of Phospholipase Activity Regulation Of Lipid Transport Negative Regulation Of Ion Transport Reactive Oxygen Species Metabolic Process Regulation Of Cell Projection Assembly Regulation Of Response To DNA Damage Stimulus Cytokine Production Cytoskeleton-dependent Intracellular Transport Regulation Of Anion Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cell Shape Negative Regulation Of Secretion Cellular Response To Oxidative Stress Positive Regulation Of Ion Transport
Tagcloud ?		adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 polr2k rpl14 rpl41 rpl8 rps17 rps24 rps5 snrpa srp9 ssh subtractive underexpressed zbtb11 zip14