PLA2G10 and MYO10

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PLA2G10	MYO10
Gene Name		phospholipase A2, group X	myosin X
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Myosin Complex Lamellipodium Filopodium Membrane Filopodium Tip Neuron Projection Neuronal Cell Body
	Molecular Function	Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding	Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Spectrin Binding Actin-dependent ATPase Activity Actin Filament Binding Plus-end Directed Microfilament Motor Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Axon Guidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonic Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Macrophage Activation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Lysophospholipid Transport Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Efflux	Axon Guidance Metabolic Process Regulation Of Cell Shape Positive Regulation Of Cell-cell Adhesion Cytoskeleton-dependent Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Filopodium Assembly
Pathways		Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS	Axon guidance Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Major depressive disorder ( 23377640) Obesity-related traits ( 23251661) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		2 interactors: MYO10 PLA2R1	6 interactors: ACTA1 CALM1 CALML3 DYNLL1 ITGB5 PLA2G10
Entrez ID		8399	4651
HPRD ID		04674	03283
Ensembl ID		ENSG00000069764	ENSG00000145555
Uniprot IDs		O15496	E7EPL7 Q9HD67
PDB IDs		1LE6 1LE7	2LW9 3AU4 3AU5 3PZD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Arachidonic Acid Secretion Negative Regulation Of Icosanoid Secretion Negative Regulation Of Phospholipase A2 Activity Positive Regulation Of Arachidonic Acid Secretion Regulation Of Arachidonic Acid Secretion Negative Regulation Of Phospholipase Activity Oxidative Stress-induced Premature Senescence Endocytosis Stress-induced Premature Senescence Regulation Of Phospholipase A2 Activity Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Positive Regulation Of Icosanoid Secretion Negative Regulation Of Lipase Activity Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Transport Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Senescence Regulation Of Fatty Acid Transport Regulation Of Signal Transduction By P53 Class Mediator Vesicle-mediated Transport Regulation Of Filopodium Assembly Positive Regulation Of Lipid Transport Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Regulation Of Phospholipase Activity Regulation Of Lipid Transport Negative Regulation Of Ion Transport Reactive Oxygen Species Metabolic Process Regulation Of Cell Projection Assembly Regulation Of Response To DNA Damage Stimulus Cytokine Production Cytoskeleton-dependent Intracellular Transport Regulation Of Anion Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cell Shape Negative Regulation Of Secretion Cellular Response To Oxidative Stress Positive Regulation Of Ion Transport	Muscle Contraction Muscle System Process Substantia Nigra Development Neural Nucleus Development Midbrain Development Actin Cytoskeleton Organization Actin Filament-based Process Lysophospholipid Transport Actomyosin Structure Organization Positive Regulation Of Transport Multicellular Organismal Development Anatomical Structure Development Skeletal Muscle Fiber Adaptation Anatomical Structure Morphogenesis Developmental Process Positive Regulation Of Ion Transport Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Cholesterol Efflux Regulation Of High Voltage-gated Calcium Channel Activity Cytoskeleton Organization Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Arachidonic Acid Secretion Skeletal Muscle Thin Filament Assembly Organelle Organization Antigen Processing And Presentation Regulation Of Arachidonic Acid Secretion Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Actin Filament Organization Skeletal Myofibril Assembly Response To Metal Ion Skeletal Muscle Adaptation Alcohol Metabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Cholesterol Transport Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Transport Negative Regulation Of Phosphorylation Positive Regulation Of Phosphoprotein Phosphatase Activity Phosphatidylinositol Acyl-chain Remodeling Positive Regulation Of Prostaglandin Secretion Stress Fiber Assembly Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Regulation Of Intracellular Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Tagcloud ?		adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 polr2k rpl14 rpl41 rpl8 rps17 rps24 rps5 snrpa srp9 ssh subtractive underexpressed zbtb11 zip14	adenocarcinoma aggressive attenuated carcinomas dissemination driven ductal edges engines filopodia inducing integrin integrins invasion metastasis motor mutant myosin predominantly profiles promoted promoting protrusions serve sets specialized tip tp53 upregulation
Tagcloud (Difference) ?		adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 polr2k rpl14 rpl41 rpl8 rps17 rps24 rps5 snrpa srp9 ssh subtractive underexpressed zbtb11 zip14	adenocarcinoma aggressive attenuated carcinomas dissemination driven ductal edges engines filopodia inducing integrin integrins invasion metastasis motor mutant myosin predominantly profiles promoted promoting protrusions serve sets specialized tip tp53 upregulation
Tagcloud (Intersection) ?