PLA2G10 and MYO10

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		PLA2G10	MYO10
Name		phospholipase A2 group X	myosin X
Structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle	Ruffle Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Myosin Complex Lamellipodium Filopodium Filopodium Membrane Filopodium Tip Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cytoskeletal Protein Binding Spectrin Binding Protein-containing Complex Binding Actin Filament Binding Plus-end Directed Microfilament Motor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Prostaglandin Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Axon Guidance Fertilization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonate Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Hair Follicle Morphogenesis Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Intestinal Stem Cell Homeostasis Macrophage Activation Cholesterol Homeostasis Regulation Of Macrophage Activation Erythrocyte Maturation Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonate Secretion Negative Regulation Of Cholesterol Efflux Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Acrosome Reaction	Signal Transduction Regulation Of Cell Shape Positive Regulation Of Cell-cell Adhesion Cytoskeleton-dependent Intracellular Transport Regulation Of Filopodium Assembly
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Regulation of actin dynamics for phagocytic cup formation Netrin-1 signaling FCGR3A-mediated phagocytosis
Drugs		Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin	None
GWAS		Cholesteryl ester levels ( 31551469 )	Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease ( 28044437 ) Circulating odd-numbered chain saturated fatty acid levels (C17:0) ( 29738550 ) Major depressive disorder ( 23377640 ) Metabolite levels ( 23823483 ) Normal facial asymmetry (deformation magnitude) ( 30631343 ) Obesity-related traits ( 23251661 ) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234 ) Polycystic ovary syndrome (adjusted for age) ( 34791234 ) Response to antidepressants (symptom remission) ( 29160301 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 )
Interacting Genes		55 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXA1 HOXC8 HR HSF4 INCA1 KPRP KRTAP10-8 KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE1F LCE2A LCE2B LCE2D LCE3A LCE5A MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 PLSCR4 POU4F3 ROR2 SAXO4 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10	10 interacting genes: ACTA1 APOBEC3C CALM1 CALML3 DYNLL1 EIF4ENIF1 ITGB5 PELI2 PLA2G10 RAPH1
Entrez ID		8399	4651
HPRD ID		04674	03283
Ensembl ID		ENSG00000069764	ENSG00000145555
Uniprot IDs		O15496	B7Z3D4 Q9HD67
PDB IDs		1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J	2LW9 3AU4 3AU5 3PZD 5I0H 5I0I 5KG8
GO Terms Enriched among Interactors		Keratinization Epidermis Development Tissue Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Protein Binding Chromatin	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Detection Of Calcium Ion Calcineurin-mediated Signaling Myelin Sheath Dynein Intermediate Chain Binding Dynein Complex Substantia Nigra Development Filopodium Cytoskeleton Sarcomere Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Integrin Alphav-beta5 Complex Platelet Activating Factor Catabolic Process Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA