ORC2 and MCM10

Number of citations of the paper that reports this interaction (PubMedID 11095689)
47

Data Source:
HPRD (in vivo, two hybrid)

		ORC2	MCM10
Description		origin recognition complex subunit 2	minichromosome maintenance 10 replication initiation factor
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Heterochromatin Origin Recognition Complex Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane	Nucleus Nucleoplasm Nucleolus Nuclear Replication Fork
	Molecular Function	DNA Replication Origin Binding Protein Binding	DNA Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation	DNA Replication DNA Replication Initiation DNA Damage Response Cell Population Proliferation
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)	Nicotine dependence symptom count ( 25555482) Survival time in esophageal squamous cell carcinoma ( 34185429)
Interacting Genes		29 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4C16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RFWD3 RIPPLY3 RPA1 RPA2 XRCC5	37 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A
Entrez ID		4999	55388
HPRD ID		03112	11297
Ensembl ID		ENSG00000115942	ENSG00000065328
Uniprot IDs		Q13416	Q7L590
PDB IDs		5C8H 5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process DNA Replication Origin Binding Chromosome, Telomeric Region Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication Nucleic Acid Metabolic Process CMG Complex Double-strand Break Repair Via Break-induced Replication Single-stranded DNA Binding Nucleobase-containing Compound Metabolic Process Recombinational Repair Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process DNA Damage Response DNA Repair Chromosome MCM Complex Double-strand Break Repair Via Homologous Recombination Nucleoplasm Origin Recognition Complex Double-strand Break Repair DNA Recombination DNA Binding Single-stranded DNA Helicase Activity Cellular Response To Stress Nucleus Macromolecule Metabolic Process Helicase Activity Negative Regulation Of Cell Cycle Phase Transition DNA Helicase Activity ATP Hydrolysis Activity Mitotic DNA Replication Initiation Negative Regulation Of Cell Cycle Process DNA Replication Checkpoint Signaling Regulation Of Cell Cycle Phase Transition Damaged DNA Binding Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Signaling ATP Binding Regulation Of Cell Cycle Process Positive Regulation Of DNA Replication Site Of DNA Damage Regulation Of Cell Cycle Protein Localization To Chromosome DNA Replication Factor A Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Mitotic G1 DNA Damage Checkpoint Signaling	DNA Replication Initiation Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Origin Binding CMG Complex Regulation Of DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region MCM Complex Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Cellular Response To Stress DNA Damage Response Origin Recognition Complex Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle DNA Recombination G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Nucleus Regulation Of Cell Cycle Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Single-stranded DNA Binding Cell Division Cyclin D1-CDK6 Complex Cyclin D3-CDK6 Complex DNA Replication Preinitiation Complex Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Single-stranded DNA Helicase Activity Centrosome Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Metabolic Process Helicase Activity DNA Repair Protein Serine/threonine Kinase Binding Mitotic Cell Cycle Phase Transition Cytoplasm Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cell Cycle Process Cell Cycle Phase Transition
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