ORC2 and ORC6

Number of citations of the paper that reports this interaction (PubMedID 11323433)
0

Data Source:
HPRD (in vitro, in vivo)

		ORC2	ORC6
Description		origin recognition complex subunit 2	origin recognition complex subunit 6
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Heterochromatin Origin Recognition Complex Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane	Origin Recognition Complex Fibrillar Center Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol Membrane
	Molecular Function	DNA Replication Origin Binding Protein Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation	DNA Replication DNA-templated DNA Replication DNA Replication Initiation
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		29 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4C16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RFWD3 RIPPLY3 RPA1 RPA2 XRCC5	20 interacting genes: APP CDC45 CDC6 CDC7 CEBPA DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2
Entrez ID		4999	23594
HPRD ID		03112	06237
Ensembl ID		ENSG00000115942	ENSG00000091651
Uniprot IDs		Q13416	Q9Y5N6
PDB IDs		5C8H 5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F	3M03 6KVG 8S0B 8S0D
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process DNA Replication Origin Binding Chromosome, Telomeric Region Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication Nucleic Acid Metabolic Process CMG Complex Double-strand Break Repair Via Break-induced Replication Single-stranded DNA Binding Nucleobase-containing Compound Metabolic Process Recombinational Repair Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process DNA Damage Response DNA Repair Chromosome MCM Complex Double-strand Break Repair Via Homologous Recombination Nucleoplasm Origin Recognition Complex Double-strand Break Repair DNA Recombination DNA Binding Single-stranded DNA Helicase Activity Cellular Response To Stress Nucleus Macromolecule Metabolic Process Helicase Activity Negative Regulation Of Cell Cycle Phase Transition DNA Helicase Activity ATP Hydrolysis Activity Mitotic DNA Replication Initiation Negative Regulation Of Cell Cycle Process DNA Replication Checkpoint Signaling Regulation Of Cell Cycle Phase Transition Damaged DNA Binding Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Signaling ATP Binding Regulation Of Cell Cycle Process Positive Regulation Of DNA Replication Site Of DNA Damage Regulation Of Cell Cycle Protein Localization To Chromosome DNA Replication Factor A Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Mitotic G1 DNA Damage Checkpoint Signaling	DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Regulation Of DNA Replication CMG Complex Nuclear Origin Of Replication Recognition Complex Nucleic Acid Metabolic Process MCM Complex Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of DNA-templated DNA Replication Initiation Nucleobase-containing Compound Metabolic Process Origin Recognition Complex Single-stranded DNA Binding Chromosome Double-strand Break Repair DNA Recombination DNA Repair Single-stranded DNA Helicase Activity DNA Damage Response Nucleoplasm Macromolecule Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Helicase Activity Cellular Response To Stress Helicase Activity DNA Replication Preinitiation Complex Regulation Of Primary Metabolic Process Mitotic DNA Replication Initiation ATP Binding Regulation Of Macromolecule Metabolic Process Chromatin Binding Regulation Of Cell Cycle Chromatin Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Cell Cycle Response To Stress Regulation Of Metabolic Process ATP Hydrolysis Activity G-rich Strand Telomeric DNA Binding Nucleotide Binding 3'-5' DNA Helicase Activity Regulation Of Nuclear Cell Cycle DNA Replication DNA Strand Elongation Involved In DNA Replication
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