ORC2 and ORC4

Number of citations of the paper that reports this interaction (PMID 11323433)
47

Data Source:
HPRD (in vivo, in vitro)

		ORC2	ORC4
Gene Name		origin recognition complex, subunit 2	origin recognition complex, subunit 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Plasma Membrane Membrane	Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Actin Cytoskeleton
	Molecular Function	DNA Replication Origin Binding Protein Binding	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle DNA Replication DNA Replication Initiation	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex	G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: CDC45 CDC5L CDC6 CDK2 CDT1 DBF4 HIST3H3 HIST4H4 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RPA1 RPA2 XRCC5	27 interactors: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 HIST3H3 HIST4H4 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RPA2 RRM2B TCF4
Entrez ID		4999	5000
HPRD ID		03112	09118
Ensembl ID			ENSG00000115947
Uniprot IDs		Q13416	A8K7H4 O43929 Q96B14
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle DNA Replication Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process Mitotic Cell Cycle DNA-dependent DNA Replication Mitotic Cell Cycle Process DNA Replication Initiation Cell Cycle Process Cell Cycle DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process DNA Duplex Unwinding DNA Geometric Change Chromosome Organization Biosynthetic Process DNA Conformation Change DNA Unwinding Involved In DNA Replication Cellular Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance Organelle Organization Cell Cycle Checkpoint DNA Replication Checkpoint Protein-DNA Complex Assembly Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process DNA Recombinase Assembly Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Double-strand Break Repair DNA Repair Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stress DNA Recombination Nucleotide-excision Repair, DNA Gap Filling	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication DNA Replication DNA Replication Initiation Cell Cycle Process Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nitrogen Compound Metabolic Process Chromosome Organization DNA Unwinding Involved In DNA Replication Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process DNA Conformation Change DNA Duplex Unwinding DNA Geometric Change Biosynthetic Process Organelle Organization Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Protein-DNA Complex Assembly Cellular Response To DNA Damage Stimulus Regulation Of DNA Recombination Telomere Maintenance Regulation Of Mitotic Cell Cycle Phase Transition Cell Proliferation Regulation Of Cell Cycle Phase Transition SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Cell Cycle Chromatin Assembly Cellular Process Cellular Macromolecular Complex Assembly Response To Epidermal Growth Factor Regulation Of Protein Export From Nucleus Chromatin Assembly Or Disassembly
Tagcloud ?		brdu budding catalytic comprising discs dpolepsilon dpolepsilonp255 dpolepsilonp58 drosophila endoreplication epsilon eye hetero homozygous imaginal instar kda larvae lethal multicellular organism ph3 polepsilon pupal replicating salivary stop strand tetrameric	archaeon cctb chec2 dpsa elfa fumc gapb halobacterium halophilic imd2 ipg msra nrc ppia rphs6 rpl18e rpl31eand rps27ae shsp thic thid tpia trh5 uvrc vng0683c vng1300h vng1807h vng6254 yufn
Tagcloud (Difference) ?		brdu budding catalytic comprising discs dpolepsilon dpolepsilonp255 dpolepsilonp58 drosophila endoreplication epsilon eye hetero homozygous imaginal instar kda larvae lethal multicellular organism ph3 polepsilon pupal replicating salivary stop strand tetrameric	archaeon cctb chec2 dpsa elfa fumc gapb halobacterium halophilic imd2 ipg msra nrc ppia rphs6 rpl18e rpl31eand rps27ae shsp thic thid tpia trh5 uvrc vng0683c vng1300h vng1807h vng6254 yufn
Tagcloud (Intersection) ?