ORC2 and MCM3

Number of citations of the paper that reports this interaction (PubMedID 12364596)
70

Data Source:
BioGRID (biochemical)
HPRD (two hybrid, in vitro)

		ORC2	MCM3
Description		origin recognition complex subunit 2	minichromosome maintenance complex component 3
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Heterochromatin Origin Recognition Complex Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Chromosome Nucleolus Cytoplasm Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex
	Molecular Function	DNA Replication Origin Binding Protein Binding	Nucleotide Binding DNA Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication Initiation
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)	Cryptococcosis in HIV infection ( 33269293)
Interacting Genes		29 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4C16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RFWD3 RIPPLY3 RPA1 RPA2 XRCC5	37 interacting genes: ATRIP CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 FILNC1 HAUS1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TRIM28 YWHAQ
Entrez ID		4999	4172
HPRD ID		03112	04072
Ensembl ID		ENSG00000115942	ENSG00000112118
Uniprot IDs		Q13416	A0A0S2Z492 A0A0S2Z4T1 A0A499FHX9 B4DUQ9 J3KQ69 P25205
PDB IDs		5C8H 5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F	6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process DNA Replication Origin Binding Chromosome, Telomeric Region Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication Nucleic Acid Metabolic Process CMG Complex Double-strand Break Repair Via Break-induced Replication Single-stranded DNA Binding Nucleobase-containing Compound Metabolic Process Recombinational Repair Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process DNA Damage Response DNA Repair Chromosome MCM Complex Double-strand Break Repair Via Homologous Recombination Nucleoplasm Origin Recognition Complex Double-strand Break Repair DNA Recombination DNA Binding Single-stranded DNA Helicase Activity Cellular Response To Stress Nucleus Macromolecule Metabolic Process Helicase Activity Negative Regulation Of Cell Cycle Phase Transition DNA Helicase Activity ATP Hydrolysis Activity Mitotic DNA Replication Initiation Negative Regulation Of Cell Cycle Process DNA Replication Checkpoint Signaling Regulation Of Cell Cycle Phase Transition Damaged DNA Binding Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Signaling ATP Binding Regulation Of Cell Cycle Process Positive Regulation Of DNA Replication Site Of DNA Damage Regulation Of Cell Cycle Protein Localization To Chromosome DNA Replication Factor A Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Mitotic G1 DNA Damage Checkpoint Signaling	DNA Replication Initiation DNA Metabolic Process DNA Replication Nucleic Acid Metabolic Process DNA Replication Origin Binding Double-strand Break Repair Via Break-induced Replication Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response CMG Complex MCM Complex Regulation Of DNA Metabolic Process Regulation Of DNA Replication DNA Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of DNA-templated DNA Replication Initiation Macromolecule Metabolic Process Nucleus Double-strand Break Repair DNA Recombination Single-stranded DNA Binding Regulation Of Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Chromosome Negative Regulation Of Cell Cycle Phase Transition Nuclear Origin Of Replication Recognition Complex Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Single-stranded DNA Helicase Activity DNA Damage Checkpoint Signaling Origin Recognition Complex Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Signal Transduction In Response To DNA Damage DNA Helicase Activity Response To Stress Sister Chromatid Cohesion Prp19 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated DNA Replication ATP Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Helicase Activity Cyclin E1-CDK2 Complex
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