OPRK1 and GABARAPL1

Number of citations of the paper that reports this interaction (PubMedID 16431922)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		OPRK1	GABARAPL1
Description		opioid receptor kappa 1	GABA type A receptor associated protein like 1
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum T-tubule Dendrite Synaptic Vesicle Membrane Sarcolemma Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Axon Terminus Postsynaptic Membrane	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Receptor Serine/threonine Kinase Binding Dynorphin Receptor Activity Neuropeptide Binding	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception Locomotory Behavior Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Insulin Positive Regulation Of Dopamine Secretion Negative Regulation Of Luteinizing Hormone Secretion Response To Nicotine G Protein-coupled Opioid Receptor Signaling Pathway Response To Cocaine Maternal Behavior Eating Behavior Response To Estrogen Estrous Cycle Response To Ethanol Regulation Of Saliva Secretion Behavioral Response To Cocaine Sensory Perception Of Temperature Stimulus Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Glucose Stimulus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Potassium Ion Transmembrane Transport Response To Acrylamide Positive Regulation Of Eating Behavior Conditioned Place Preference	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Glycophagy Autophagosome Maturation
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates neuronal receptors and channels	Macroautophagy
Drugs		Tramadol Atomoxetine Morphine Codeine Amitriptyline Hydromorphone Mirtazapine Progesterone Meperidine Oxycodone Dextromethorphan Lamotrigine Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Fentanyl Levomenthol Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Naloxone Dezocine Ketamine Aripiprazole 3-Methylthiofentanyl Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Asimadoline CR665 ADL 10-0101 Mianserin Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Methylnaltrexone Butyrfentanyl Pholcodine Eluxadoline Opium Pentoxyverine Naldemedine Difelikefalin Samidorphan Loxicodegol
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Body size at age 10 ( 32376654) IgE levels in asthmatics (D.p. specific) ( 23967269) Modic changes ( 30808802) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373)
Interacting Genes		6 interacting genes: GABARAPL1 GNA15 GPRASP1 NHERF1 NKG7 OPRD1	87 interacting genes: AHNAK2 AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG4A ATG4B ATG4D AZI2 BICC1 BNIP3L BRD9 BSCL2 BSDC1 CALCOCO1 CALCOCO2 CARS2 CCT2 CDC37 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 G3BP1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAP4K2 MAPK15 MEFV MLX MYBPC1 NCOR1 NEDD4 NFIA NUFIP2 OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RESF1 RETREG3 SCYL3 SEC62 SNCA SQSTM1 SRPK1 SRPK2 STK3 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 UMAD1 VDR WDFY3 ZBTB22
Entrez ID		4986	23710
HPRD ID		01309	07601
Ensembl ID		ENSG00000082556	ENSG00000139112
Uniprot IDs		A0A5F9ZI09 P41145	Q9H0R8
PDB IDs		4DJH 6B73 6VI4 7T10 7T11 7UL2 7UL3 7UL5 7Y1F 7YIT 7YMJ 8DZP 8DZQ 8DZR 8DZS 8F7W 8FEG 8HNN 8K2W 8VVE 8VVF 8VVG 9D61	2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL 6YOO 7AA7 7AA9 7JHX 8X8A
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target G Protein-coupled Enkephalin Receptor Activity Renal Phosphate Ion Absorption Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding G Protein-coupled Receptor Catabolic Process Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Natural Killer Cell Degranulation Cytolytic Granule Membrane Immune Response To Tumor Cell Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle Receptor Serine/threonine Kinase Binding G Protein-coupled Opioid Receptor Activity Spine Apparatus Microvillus Organization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Type 3 Metabotropic Glutamate Receptor Binding Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding G Protein-coupled Opioid Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Cellular Response To Toxic Substance Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport Golgi Localization Maintenance Of Cell Polarity Glutathione Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cerebrospinal Fluid Circulation Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Tat Protein Binding Glycophagy Plasma Membrane Protein Complex	Autophagosome Regulation Of Cilium Assembly Autophagy Macroautophagy GTPase Activator Activity Regulation Of Organelle Assembly Cytosol Regulation Of Autophagy Positive Regulation Of Autophagy Autophagy Of Mitochondrion Regulation Of Cell Projection Assembly Mitophagy Autophagosome Assembly Autophagosome Organization Aggrephagy Cytoplasmic Vesicle Piecemeal Microautophagy Of The Nucleus Cytoplasm Regulation Of Cell Projection Organization Microautophagy Nucleophagy Positive Regulation Of Catabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Protein-phosphatidylethanolamide Deconjugating Activity Catabolic Process Protein Delipidation Response To Mitochondrial Depolarisation Organelle Assembly Regulation Of Macroautophagy Atg1/ULK1 Kinase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macroautophagy Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Phagophore Assembly Site Negative Regulation Of Signal Transduction ERBB3:ERBB2 Complex Protein Localization To Phagocytic Vesicle Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Viral Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?