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OPRK1 and GNA15
Number of citations of the paper that reports this interaction (PMID
9572309
)
8
Data Source:
HPRD
(in vivo)
OPRK1
GNA15
Gene Name
opioid receptor, kappa 1
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Neuron Projection
Heterotrimeric G-protein Complex
Plasma Membrane
Molecular Function
Opioid Receptor Activity
Protein Binding
Dynorphin Receptor Activity
Neuropeptide Binding
G-protein Coupled Receptor Binding
GTPase Activity
Signal Transducer Activity
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
Metal Ion Binding
Biological Process
Immune Response
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Neuropeptide Signaling Pathway
Synaptic Transmission
Sensory Perception
Behavior
Locomotory Behavior
Sensory Perception Of Pain
Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway
Opioid Receptor Signaling Pathway
Regulation Of Saliva Secretion
Defense Response To Virus
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway
Blood Coagulation
Platelet Activation
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Signaling by GPCR
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
Regulation of insulin secretion
Signal amplification
Thrombin signalling through proteinase activated receptors (PARs)
G alpha (q) signalling events
GPCR downstream signaling
Acetylcholine regulates insulin secretion
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
Platelet activation, signaling and aggregation
Free fatty acids regulate insulin secretion
Drugs
Tramadol
Morphine
Codeine
Amitriptyline
Hydromorphone
Mirtazapine
Meperidine
Oxycodone
Butorphanol
Propoxyphene
Pentazocine
Naltrexone
Sufentanil
Fentanyl
Menthol
Loperamide
Nalbuphine
Levorphanol
Remifentanil
Buprenorphine
Naloxone
Dezocine
3-Methylthiofentanyl
Heroin
Etorphine
Carfentanil
Diprenorphine
Dihydromorphine
3-Methylfentanyl
Tapentadol
Alvimopan
Methylnaltrexone
Diseases
GWAS
Heart failure (
20445134
)
Protein-Protein Interactions
5 interactors:
GABARAPL1
GNA15
GPRASP1
OPRD1
SLC9A3R1
19 interactors:
ADRB2
ADRBK1
APP
CHRM2
CNR1
CNR2
CXCR1
CXCR2
F2R
GRM2
GRM4
HRH4
LTB4R
OPRD1
OPRK1
OPRM1
PRKCA
RGS2
TTC1
Entrez ID
4986
2769
HPRD ID
01309
00760
Ensembl ID
ENSG00000082556
ENSG00000060558
Uniprot IDs
P41145
P30679
PDB IDs
2A0D
2IQN
4DJH
Enriched GO Terms of Interacting Partners
?
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Dopamine Receptor Signaling Pathway
Renal Phosphate Ion Absorption
Glutathione Transport
G-protein Coupled Receptor Catabolic Process
Negative Regulation Of Sodium:proton Antiporter Activity
Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway
Renal Sodium Ion Transport
G-protein Coupled Receptor Signaling Pathway
Cellular Phosphate Ion Homeostasis
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Regulation Of Sodium:proton Antiporter Activity
Negative Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Protein Oligomerization
Bile Acid Secretion
Opioid Receptor Signaling Pathway
Oligopeptide Transport
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Renal Absorption
Regulation Of Proton Transport
Phosphate Ion Homeostasis
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Microvillus Assembly
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Microvillus Organization
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Cellular Ion Homeostasis
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of CREB Transcription Factor Activity
Receptor Catabolic Process
Nucleophagy
Cellular Chemical Homeostasis
Cellular Response To Toxic Substance
Regulation Of Excretion
Ion Homeostasis
Regulation Of Sensory Perception Of Pain
Mitochondrion Degradation
Regulation Of Protein Oligomerization
Regulation Of Sodium Ion Transmembrane Transporter Activity
Protein Import Into Nucleus, Translocation
Endosome To Lysosome Transport
Regulation Of Ion Transport
Bile Acid And Bile Salt Transport
Regulation Of Mitochondrial Membrane Potential
Regulation Of Sodium Ion Transmembrane Transport
Cytoplasmic Transport
G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Defense Response
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Signaling
Cell Communication
Sensory Perception Of Pain
Cellular Metal Ion Homeostasis
Inflammatory Response
Response To External Stimulus
Opioid Receptor Signaling Pathway
Cellular Cation Homeostasis
Cellular Response To Stimulus
Cellular Ion Homeostasis
Metal Ion Homeostasis
Regulation Of Phosphorus Metabolic Process
Cellular Chemical Homeostasis
Blood Circulation
Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Muscle Contraction
Response To Stress
Chemical Homeostasis
Ion Homeostasis
Synaptic Transmission
Regulation Of Cyclase Activity
Immune Response
Regulation Of Phosphorylation
Cytosolic Calcium Ion Homeostasis
Regulation Of MAPK Cascade
Regulation Of Catalytic Activity
Homeostatic Process
Regulation Of Signaling
Interleukin-8-mediated Signaling Pathway
Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway
Cellular Homeostasis
Negative Regulation Of Muscle Contraction
Negative Regulation Of Adenylate Cyclase Activity
Regulation Of CAMP Biosynthetic Process
Negative Regulation Of Lyase Activity
Response To Stimulus
Regulation Of CAMP Metabolic Process
Regulation Of Sensory Perception Of Pain
Negative Regulation Of Catalytic Activity
Tagcloud
?
anomalies
behind
bioinformatics
cart
ctf
dependence
depicting
ebpbeta
elaborate
govern
instance
intron
likewise
modify
nfya
nutshell
pdyn
pdyns
pharmaceutical
prodynorphin
prompting
regimes
retrieve
snps
tbp
usf
usf2
vdr
vulnerability
Tagcloud (Difference)
?
anomalies
behind
bioinformatics
cart
ctf
dependence
depicting
ebpbeta
elaborate
govern
instance
intron
likewise
modify
nfya
nutshell
pdyn
pdyns
pharmaceutical
prodynorphin
prompting
regimes
retrieve
snps
tbp
usf
usf2
vdr
vulnerability
Tagcloud (Intersection)
?