OPRK1 and OPRD1

Number of citations of the paper that reports this interaction (PMID 11069979)
95

Data Source:
HPRD (in vivo)

		OPRK1	OPRD1
Gene Name		opioid receptor, kappa 1	opioid receptor, delta 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Plasma Membrane Vesicle Dendrite Membrane Neuron Projection Axon Terminus Membrane Raft Postsynaptic Membrane
	Molecular Function	Opioid Receptor Activity Protein Binding Dynorphin Receptor Activity Neuropeptide Binding	Opioid Receptor Activity Protein Binding Enkephalin Receptor Activity Neuropeptide Binding
	Biological Process	Immune Response Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Sensory Perception Behavior Locomotory Behavior Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Opioid Receptor Signaling Pathway Regulation Of Saliva Secretion Defense Response To Virus	Protein Import Into Nucleus, Translocation Immune Response G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Adult Locomotory Behavior Negative Regulation Of Gene Expression Sensory Perception Of Pain Negative Regulation Of Protein Oligomerization Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Opioid Receptor Signaling Pathway Regulation Of Mitochondrial Membrane Potential Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Response To Toxic Substance
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Tramadol Morphine Codeine Amitriptyline Hydromorphone Mirtazapine Meperidine Oxycodone Butorphanol Propoxyphene Pentazocine Naltrexone Sufentanil Fentanyl Menthol Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Naloxone Dezocine 3-Methylthiofentanyl Heroin Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl Tapentadol Alvimopan Methylnaltrexone	Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Oxycodone Butorphanol Propoxyphene Naltrexone Sufentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone 3-Methylthiofentanyl Dimethylthiambutene Heroin Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl Tapentadol Alvimopan
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GABARAPL1 GNA15 GPRASP1 OPRD1 SLC9A3R1	16 interactors: ADRB2 ADRBK1 ARRB1 ARRB2 GNA15 GNAI1 GNAI2 GNAO1 GNAZ GPRASP1 KLHL3 OPRK1 OPRM1 PRKCA PRKCD PRKCE
Entrez ID		4986	4985
HPRD ID		01309	01308
Ensembl ID		ENSG00000082556	ENSG00000116329
Uniprot IDs		P41145	P41143
PDB IDs		2A0D 2IQN 4DJH	1OZC 2IQM
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dopamine Receptor Signaling Pathway Renal Phosphate Ion Absorption Glutathione Transport G-protein Coupled Receptor Catabolic Process Negative Regulation Of Sodium:proton Antiporter Activity Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Renal Sodium Ion Transport G-protein Coupled Receptor Signaling Pathway Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Oligomerization Bile Acid Secretion Opioid Receptor Signaling Pathway Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Phosphate Ion Homeostasis G-protein Coupled Acetylcholine Receptor Signaling Pathway Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Ion Homeostasis Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of CREB Transcription Factor Activity Receptor Catabolic Process Nucleophagy Cellular Chemical Homeostasis Cellular Response To Toxic Substance Regulation Of Excretion Ion Homeostasis Regulation Of Sensory Perception Of Pain Mitochondrion Degradation Regulation Of Protein Oligomerization Regulation Of Sodium Ion Transmembrane Transporter Activity Protein Import Into Nucleus, Translocation Endosome To Lysosome Transport Regulation Of Ion Transport Bile Acid And Bile Salt Transport Regulation Of Mitochondrial Membrane Potential Regulation Of Sodium Ion Transmembrane Transport Cytoplasmic Transport	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation G-protein Coupled Receptor Signaling Pathway Wound Healing Cell Surface Receptor Signaling Pathway Blood Coagulation Hemostasis Response To Wounding Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Body Fluid Levels Regulation Of MAPK Cascade Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Cell Activation Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Stress Positive Regulation Of MAPK Cascade Negative Regulation Of Signaling Regulation Of Catalytic Activity Signal Transduction Regulation Of Adenylate Cyclase Activity Regulation Of Ion Transport G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Cyclase Activity Signaling Positive Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Cell Communication Receptor Metabolic Process Regulation Of CAMP Biosynthetic Process Locomotory Behavior Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Lyase Activity Positive Regulation Of Signal Transduction Regulation Of CAMP Metabolic Process Response To External Stimulus Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Negative Regulation Of CAMP Biosynthetic Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process
Tagcloud ?		anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nfya nutshell pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp usf usf2 vdr vulnerability	10kb appbp2 arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Difference) ?		anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nfya nutshell pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp usf usf2 vdr vulnerability	10kb appbp2 arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Intersection) ?