ATP2B4 and DLG3

Number of citations of the paper that reports this interaction (PubMedID 11274188)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ATP2B4	DLG3
Description		ATPase plasma membrane Ca2+ transporting 4	discs large MAGUK scaffold protein 3
Image
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Caveola Cilium Membrane Basolateral Plasma Membrane Z Disc T-tubule Motile Cilium Protein-containing Complex Ciliary Basal Body Sperm Flagellum Sarcolemma Cell Projection Intracellular Membrane-bounded Organelle Membrane Raft Presynaptic Active Zone Membrane Sperm Principal Piece Glutamatergic Synapse	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding P-type Calcium Transporter Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Sodium Channel Regulator Activity Protein Kinase Binding PDZ Domain Binding Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Nitric-oxide Synthase Binding Scaffold Protein Binding	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Neural Retina Development Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Spermatogenesis Negative Regulation Of Gene Expression Urinary Bladder Smooth Muscle Contraction Negative Regulation Of Angiogenesis Hippocampus Development Flagellated Sperm Motility Monoatomic Ion Transmembrane Transport Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cytosolic Calcium Ion Concentration Response To Hydrostatic Pressure Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Transport Across Blood-brain Barrier Negative Regulation Of Arginine Catabolic Process Calcium Ion Export Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Regulation Of Cardiac Conduction Cellular Response To Acetylcholine	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Ritodrine Halothane Desflurane Sevoflurane
Diseases			Non-syndromic X-linked mental retardation
GWAS		Appendicular lean mass ( 33097823) Breast size ( 22747683) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Glycated hemoglobin levels ( 34059833) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494 27863252) Malaria ( 22895189 31844061) Mean corpuscular hemoglobin concentration ( 23263863 27863252 32888494 28453575) Mean corpuscular volume ( 27863252 32888494) Monocyte count ( 32888494) Obstructive sleep apnea (average oxygen saturation during sleep) ( 26977737) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)	Mean platelet volume ( 32888494)
Interacting Genes		11 interacting genes: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBIN NOS1 PPP3CA RASSF1 SRC	51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN
Entrez ID		493	1741
HPRD ID		00159	02177
Ensembl ID		ENSG00000058668	ENSG00000082458
Uniprot IDs		P23634	Q59FY1 Q92796
PDB IDs		1CFF 2KNE	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Ionotropic Glutamate Receptor Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Cell Adhesion GMP Kinase Activity Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Cell Polarity GDP Metabolic Process Protein Localization To Synapse Cell Junction Protein Localization To Cell Junction Basolateral Plasma Membrane Kinase Binding Postsynaptic Density Membrane GMP Metabolic Process Synaptic Signaling Regulation Of Biological Quality Positive Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Adherens Junction Cell-cell Junction Synapse Scaffold Protein Binding Regulation Of Transport Plasma Membrane Regulation Of Vesicle-mediated Transport Nucleoside Monophosphate Metabolic Process Postsynaptic Density Ribonucleoside Diphosphate Metabolic Process Regulation Of System Process Glutamatergic Synapse Nucleoside Diphosphate Metabolic Process Cell-cell Signaling Basement Membrane Juxtaparanode Region Of Axon Signaling Intracellular Protein Localization Cell Periphery Regulation Of Endocytosis Cell Communication Chemical Synaptic Transmission Protein Localization To Membrane Cellular Response To Potassium Ion Sarcolemma Neuron Projection Trans-synaptic Signaling Regulation Of Metal Ion Transport	Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?